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ProteomicsFrom birth to bite: the evolutionary ecology of India's medically most important snake venoms
Venoms of N. naja and D. russelii individuals of various developmental stages, including neonates (<30 days), juveniles (between 1 to 12 months), and mature individuals (>36 months), were sampled with permission from the state forest department of Karnataka. 226 individuals and 9 clutches were examin...
ORGANISM(S): Daboia russelii Naja naja 
2024-08-10 | PXD046781 | Pride
Thermofisher orbitrap fusion mass spectrometry Snake venom Daboia russelii Venom proteomics Naja naja Ontogeny 
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ProteomicsTyrosine-1 of RNA polymerase II CTD controls global termination of gene transcription in mammals
The aim of the project was to analyse the functional role of Tyrosine-1 of mammalian RNA polymerase II CTD in the regulation of transcription-coupled processes. We studied mammalian CTD mutants to analyze the function of tyrosine1 residues. Mutation of 3/4 of the tyrosine residues in a mutant YFFF r...
ORGANISM(S): Homo sapiens (Human) 
2018-01-09 | PXD008270 | Pride
Tyrosine1 Transcription termination Promoter-proximal pausing Read-through transcription Divergent transcription. Ctd Rna polymerase ii 
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ProteomicsCleavage of Cartilage Oligomeric Matrix Protein (COMP) by ADAMTS4 generates a neoepitope associated with osteoarthritis severity and progression
The major proteoglycan in cartilage is COMP. This protein undergoes extensive proteolytic turnover that is believed to be dysregulated during osteoarthritis. Here we identify and describe two secreted proteases that are responsible for this turnover and identify the specific sites of proteolysis by e...
ORGANISM(S): Homo sapiens (Human) 
2025-02-26 | PXD057263 | Pride
Comp Proteoglycan Osteoarthritis Adamts5 Adamts1 
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MetabolomicsMetabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system
Toxicity testing is vital to protect human health from exposure to toxic chemicals in the environment. Furthermore, combining novel cellular models with molecular profiling technologies, such as metabolomics can add new insight into the molecular basis of toxicity and provide a rich source of biomark...
2017-09-18 | MTBLS9 | MetaboLights
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Metabolomics,MultiomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compared...
2015-11-19 | MTBLS143 | MetaboLights
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ProteomicsEffect of POR knockdown on the proteome of HepaRG cells
Cytochrome P450 oxidoreductase (POR) is involved in the oxidative metabolism of xenobiotics and endogenous compounds like fatty acid and cholesterol. While effects of diminished Por were extensively studied in mouse models, studies in human models are still missing. We used previously established CRI...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD028577 | Pride
Proteomics Heparg Bile acid metabolism Crispr/cas9 Cholesterol biosynthesis Nadph cytochrome p450 reductase 
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ProteomicsIdentification of the protein interaction network of STAG2 protein isoforms with inclusion and exclusion of exon32
This study involves the identification of specific interactors for STAG2ex32+ and STAG2ex32delta. Plasmids expressing YFP-STAG2 isoforms were transfected into HCT116OsTIR cells using untransfected cells as mock control. 40h post transfection, whole cell lysates were extracted and STAG2 isoforms were ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD041975 | Pride
Ap-ms 
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UnknownMultianalytical Approach to Understand Polyphenol-Mal d 1 Interactions to Predict Their Impact on the Allergenic Potential of Apples.
Not available
S-EPMC11273618 | biostudies-literature
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ProteomicsElectroneutral polymer nanodiscs enable interference-free probing of membrane proteins in a lipid-bilayer environment
Membrane proteins can be examined in near-native lipid-bilayer environments with the advent of polymer-encapsulated nanodiscs. These nanodiscs self-assemble directly from cellular membranes, allowing in vitro probing of membrane proteins with techniques that had previously been restricted to soluble ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD030958 | Pride
Membrane proteins Dibma nanodiscs 
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ProteomicsCLUH-dependent RNA granules coordinate mitochondrial catabolic pathways with mTORC1 signaling and mitophagy
Mitochondria house anabolic and catabolic processes that must be balanced and rapidly adjusted to meet the cellular demands. CLUH binds mRNAs of nuclear encoded mitochondrial proteins and is highly expressed in the liver, where it regulates metabolic plasticity by an ill-defined mechanism. Here, we s...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-19 | PXD014098 | Pride
Mitochondria Catabolism Rna-binding proteins 
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