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ProteomicsRescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub
Authors: Marc P. Forrest1,2, Marc Dos Santos1,2, Nicolas H. Piguel1,2, Yi-Zhi Wang3, Nicole A. Hawkins4, Vikram A. Bagchi1,2, Leonardo E. Dionisio1,2, Sehyoun Yoon1,2, Dina Simkin3,4, Maria Dolores Martin-de-Saavedra1,2, Ruoqi Gao1,2, Katherine E. Horan1,2, Alfred L. George Jr.2,4, Mark S. LeDoux5,6...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-12-12 | MSV000090884 | MassIVE
MetabolomicsThe impact of nutritional supplementation on sweat metabolomic content
Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat col...
2021-03-15 | MTBLS2427 | MetaboLights
MetabolomicsUntargeted Metabolomics for Integrative Taxonomy: Metabolomics, DNA Marker-Based Sequencing, and Phenotype Bioimaging

Integrative taxonomy is a fundamental part of biodiversity and combines traditional morphology with additional methods such as DNA sequencing or biochemistry. Here, we aim to establish untargeted metabolomics for use in chemotaxonomy. We used three thallose liverwort species Riccia glauca

2026-01-30 | MTBLS4668 | MetaboLights
TranscriptomicsTranscriptomic response of Elodea nuttallii to heavy metals
The mechanisms of heavy metal accumulation in primary producers and the damage and stress response induced by heavy metals is not well understood. We used UHTS to analyze the transcriptomic response of Elodea nuttallii to heavy metal pollution. We exposed shoots of E. nuttallii for 24 h to increasin...
ORGANISM(S): Elodea nuttallii 
2012-02-01 | E-MTAB-892 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast Gcn4 and Arr1 deletion mutant as well as Gcn4 Arr1 double deletion mutant.
Transcription profiling of wild type yeast strain as well as strains carrying a deletion of Gcn4, Arr1 or both. Gene expression in rich medium (YPD) and under osmotic stress conditions (YPD + 0.8M NaCl) was compared.
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-25 | E-MEXP-3566 | biostudies-arrayexpress
TranscriptomicsMicroRNA-182-5p targets a network of genes involved in DNA repair
MicroRNAs are non-coding regulators of gene expression, which act by repressing protein translation and/or degrading mRNA. Many have been shown to drive tumorigenesis in cancer, but functional studies to understand their mode of action are typically limited to single target genes. In this study we u...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-38593 | biostudies-arrayexpress
TranscriptomicsMiz1 is required to maintain autophagic flux_2
To isolate neuronal progenitor cells (NPCs), forebrains of E13.5 Miz1+/+ or Miz1-delta-POZ embryos were cut in small pieces, digested with trypsin and filtered through sterile gauze. Cells were cultivated in 2:1 DMEM/F12 supplemented with 1xB27 (Life technologies), 20 ng/ul EGF (Biomol), 20 ng/?l ba...
ORGANISM(S): Mus musculus 
2013-10-01 | E-MEXP-3883 | biostudies-arrayexpress
TranscriptomicsIdentification of Adaptive mutations in the influenza A virus non-structural 1 gene that increase cytoplasmic localization and differentially regulate host gene expression
The NS1 protein of influenza A virus (IAV) is a multifunctional virulence factor. Mouse adaptive mutations in the NS1 protein of the human isolate A/Hong Kong/1/1968(H3N2) (HK) have been previously reported to increase virulence, viral fitness, and interferon antagonism, but differ in binding to pos...
ORGANISM(S): Mus musculus 
2013-06-22 | E-GEOD-48217 | biostudies-arrayexpress
TranscriptomicsMiz1 is required to maintain physiological levels of autophagic flux_1
Mice: knock-out of the Miz1 POZ-domain in brain (Miz1DPOZNes) and control mice. The RNA expression in cerebella of of old Miz1 delta POZ mice (1.5 years), old control mice (1.5 years), young Miz1 delta POZ mice (5.5 weeks) and young control mice (5.5 weeks) was compared
ORGANISM(S): Mus musculus 
2013-10-01 | E-MEXP-3878 | biostudies-arrayexpress
TranscriptomicsExpression data from pure/mixed brain, liver and lung to test feasability and sensitivity of statistical deconvolution
Tissues are often made up of multiple cell-types. Blood, for example, contains many different cell-types, each with its own functional attributes and molecular signature. In humans, because of its accessibility and immune functionality, blood cells have been used as a source for RNA-based biomarkers...
ORGANISM(S): Rattus norvegicus 
2010-04-06 | E-GEOD-19830 | biostudies-arrayexpress
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