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UnknownChemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K.
Not available
S-EPMC3428850 | biostudies-literature
ProteomicsChemical and phosphoproteomics illuminate the cellular mode of action of AKT inhibitors
Due to its key role in dysregulated cellular signaling in cancer, AKT has been subject to intense drug discovery efforts leading to small molecule inhibitors investigated in clinical trials, notably breast cancer. To shed more light on how these drugs exert their therapeutic effects, we integrated c...
ORGANISM(S): Homo Sapiens 
2022-01-21 | PXD015188 | panorama
UnknownPhase IB Study of Selinexor, a First-in-Class Inhibitor of Nuclear Export, in Patients With Advanced Refractory Bone or Soft Tissue Sarcoma.
Not available
S-EPMC5321073 | biostudies-literature
TranscriptomicsPten loss and RAS/MAPK activation cooperate to promote EMT and prostate cancer metastasis initiated from stem/progenitor cells
PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic burden that frequently accompanies the end stage of human disease. To identify...
ORGANISM(S): Mus musculus 
2012-02-28 | E-GEOD-34839 | biostudies-arrayexpress
TranscriptomicsAKT antagonist AZD5363 influences estrogen receptor function in endocrine resistant breast cancer and synergizes with fulvestrant (ICI182780) in vivo
Phosphoinositide-3-kinase/protein-kinaseB/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling plays an important role in breast cancer (BC). Its interaction with estrogen receptor (ER) signalling becomes more complex and inter-dependent with acquired endocrine resistance. Targeting mTOR combine...
ORGANISM(S): Homo sapiens 
2015-06-29 | E-GEOD-69893 | biostudies-arrayexpress
ProteomicsCombined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor
AKT activation is a hallmark of IM resistance in GIST. The presence of an additional therapeutic agent could potentially suppress the growth and survival of a clone of cancer cells, which have developed resistance to IM. Simultaneous targeting of AKT in addition to inhibiting KIT with IM has potenti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-20 | MSV000086739 | MassIVE
TranscriptomicsResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
We explored potential bypass mechanisms to PI3K/mTOR-directed therapy in KRAS mutant CRC models, utilizing genetically engineered mouse models (GEMM) to generate acquired resistance to the targeted dual PI3K/mTOR small molecule inhibitor PF-04691502. Transcriptomic analysis revealed a dynamic stem-l...
ORGANISM(S): Mus musculus 
2014-08-31 | E-MTAB-2510 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human non anaplastic T-cell lymphoma biopsies and cell lines
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Affymetrix HG-U133 Plus 2.0 : 7 NKTCL biopsies, 2 NKTCL cell lines (SNK6, SNT8), 16 PTCL NOS biopsies, 2 NK cells samples | Biopsies and cell lines of NK/T-cell lymphoma, na...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-TABM-702 | biostudies-arrayexpress
UnknownSeeds as Potential Sources of Phenolic Compounds and Minerals for the Indian Population.
Not available
S-EPMC9144825 | biostudies-literature
UnknownHigh-viscosity injector-based pink-beam serial crystallography of microcrystals at a synchrotron radiation source.
Not available
S-EPMC6503920 | biostudies-literature
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