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Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights

Understanding how the microbiota produces regulatory metabolites is of significance for cancer and cancer therapy. Using a host-microbe-drug-nutrient 4-way screening approach, we evaluated the role of nutrition at the molecular level in the context of 5-fluorouracil toxicity. Notably, our screens...

2025-09-16 | MTBLS9994 | MetaboLights

Understanding how the microbiota produces regulatory metabolites is of significance for cancer and cancer therapy. Using a host-microbe-drug-nutrient 4-way screening approach, we evaluated the role of nutrition at the molecular level in the context of 5-fluorouracil toxicity. Notably, our screens...

2025-09-16 | MTBLS9991 | MetaboLights
Escherichia coli A-03_34 Genome sequencing

AIM: Low-molecular-weight organic substances (LMWOSs) are at the nexus between micro-organisms, plant roots, detritus and the soil mineral matrix. The nominal oxidation state of carbon (NOSC) has been suggested as a potential parameter for modelling microbial uptake rates of LMWO...

2023-08-14 | MTBLS3558 | MetaboLights
Martinez-Guimera2017 - Generic negative feedforward circuit (Model 5) This model is described in the article: 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age. Martinez Guimera A, Welsh CM, Proctor CJ, McArdle A, Shanley DP. Mech. Ageing De...
Martinez-Guimera2017 - Generic negative feedback circuit (Model 4) This model is described in the article: 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age. Martinez Guimera A, Welsh CM, Proctor CJ, McArdle A, Shanley DP. Mech. Ageing Dev. ...
Martinez-Guimera2017 - Generic redox signalling model without negative regulation (Model 1) This model is described in the article: 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age. Martinez Guimera A, Welsh CM, Proctor CJ, McArdle A, Shanley...
Martinez-Guimera2017 - Generic redox signalling model with negative feedforward regulation (Model 3) This model is described in the article: 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age. Martinez Guimera A, Welsh CM, Proctor CJ, McArdle A...
Martinez-Guimera2017 - Generic redox signalling model with negative feedback regulation (Model 2) This model is described in the article: 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age. Martinez Guimera A, Welsh CM, Proctor CJ, McArdle A, S...
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