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GenomicsGenome-wide maps of RAP1 binding sites.
By performing chromatin immunoprecipitation coupled with ultra-high-throughput sequencing (ChIP-seq), we find that RAP1 binds to telomeres as well as to extra-telomeric sites through the (TTAGGG)2 consensus motif. Extra-telomeric RAP1 binding sites are particularly abundant at subtelomeric regions, ...
ORGANISM(S): Mus musculus 
2010-07-10 | E-GEOD-20867 | biostudies-arrayexpress
TranscriptomicsRoles of mammalian Rap1 in TERT recruitment to chromatin, subtelomeric gene silencing and transcriptional regulation
Repressor-activator protein 1 (scRap1) is the major binding activity at Saccharomyces cerevisiae telomeres, with roles in telomere length regulation and establishment of subtelomeric silencing by recruiting the Sir proteins. scRap1 also acts as a transcription factor controlling the expression of ri...
ORGANISM(S): Mus musculus 
2010-07-10 | E-GEOD-19011 | biostudies-arrayexpress
UnknownThe Low Variability of Tc24 in Trypanosoma cruzi TcI as an Advantage for Chagas Disease Prophylaxis and Diagnosis in Mexico.
Not available
S-EPMC10057631 | biostudies-literature
TranscriptomicsRAP1 protects from obesity, diabetes and metabolic syndrome through its extra telomeric role regulating gene expression (old mouse liver)
RAP1 is one of the components of shelterin, the capping complex at chromosome ends or telomeres. Unlike other shelterins, however, RAP1 is not essential for preventing telomere fusions. RAP1 also binds along chromosome arms, where it is proposed to regulate gene expression. To investigate the non-te...
ORGANISM(S): Mus musculus 
2013-06-21 | E-GEOD-43173 | biostudies-arrayexpress
TranscriptomicsRAP1 protects from obesity, diabetes and metabolic syndrome through its extra telomeric role regulating gene expression (young mouse liver)
RAP1 is one of the components of shelterin, the capping complex at chromosome ends or telomeres. Unlike other shelterins, however, RAP1 is not essential for preventing telomere fusions. RAP1 also binds along chromosome arms, where it is proposed to regulate gene expression. To investigate the non-te...
ORGANISM(S): Mus musculus 
2013-06-21 | E-GEOD-43171 | biostudies-arrayexpress
TranscriptomicsRAP1 protects from obesity, diabetes and metabolic syndrome through its extra telomeric role regulating gene expression (young mouse white fat)
RAP1 is one of the components of shelterin, the capping complex at chromosome ends or telomeres. Unlike other shelterins, however, RAP1 is not essential for preventing telomere fusions. RAP1 also binds along chromosome arms, where it is proposed to regulate gene expression. To investigate the non-te...
ORGANISM(S): Mus musculus 
2013-06-21 | E-GEOD-43172 | biostudies-arrayexpress
UnknownBiocatalytic Properties and Structural Analysis of Eugenol Oxidase from Rhodococcus jostii RHA1: A Versatile Oxidative Biocatalyst.
Not available
S-EPMC5089669 | biostudies-literature
UnknownTideglusib, a Non-ATP Competitive Inhibitor of GSK-3β as a Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis.
Not available
S-EPMC8396476 | biostudies-literature
TranscriptomicsMolecular Signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17-AAG, in breast cancer.
We have done transcriptional profiling of 17-AAG treated (24h, 48H) breast cancer cell lines to understand the mechanisms of the drug action and indicate novel set of pharmacodynamic biomarkers of the drug response as well as of resistance Two-condition experiment, Untreated vs. Treated sensitive c...
ORGANISM(S): Homo sapiens 
2010-10-11 | E-GEOD-23209 | biostudies-arrayexpress
TranscriptomicsIntegration of BRCA1-mediated miRNA and mRNA signatures reveal miR-146a, miR-99b and miR-205 regulation of the TRAF2 and NFkB pathways (mRNA dataset)
BRCA1 deregulation is a frequent event in the pathogenesis of breast as well as other cancers. In addition to the DNA repair functions of BRCA1, it is involved in a wide range of cellular processes such as cell cycle, chromatin remodeling or transcription. However, the molecular events underlying BR...
ORGANISM(S): Homo sapiens 
2011-12-24 | E-GEOD-30821 | biostudies-arrayexpress
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