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UnknownIntranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patients.

Background

By end December of 2021, COVID-19 has infected around 276 million individuals and caused over 5 million deaths worldwide. Infection results in dysregulated systemic inflammation, multi-organ dysfunction, and critical illness. Cells of the central nervous system are also affected, ...
S-EPMC8845269 | biostudies-literature
UnknownTranscriptome and metabolite profiles reveal differential molecular responses of wild and cultivated amaranth species to water deficit and salt stress.

Main conclusion

A. hybridus tolerance to salinity depends on constitutively active mechanisms, whereas A. hypochondriacus tolerance to salt and water deficit depends on a constitutive protection and a robust transcriptional response. Drought and soil salinity are two environmental factors th...
S-EPMC12855421 | biostudies-literature
UnknownRelation of the average interaction field with the coercive and interaction field distributions in First order reversal curve diagrams of nanowire arrays.
First-order reversal curve diagrams, or FORC diagrams, have been studied to determine if the widths of their distributions along the interaction and coercivity axes can be related to the mean-field magnetization dependent interaction field (MDIF). Arrays of nanowires with diameters ranging from 18 u...
S-EPMC7721885 | biostudies-literature
UnknownNLRP3 Inflammasome: The Stormy Link Between Obesity and COVID-19.
Several countries around the world have faced an important obesity challenge for the past four decades as the result of an obesogenic environment. This disease has a multifactorial origin and it is associated with multiple comorbidities including type 2 diabetes, hypertension, osteoarthritis, metabo...
S-EPMC7662564 | biostudies-literature
UnknownDillapiole, isolated from Peperomia pellucida, shows gastroprotector activity against ethanol-induced gastric lesions in Wistar rats.
Peperomia pellucida is a plant used in traditional medicine to treat gastric ulcers. Although this gastroprotective activity was reported, the active compounds have not been identified. Therefore, the aim herein was to identify the most active compound in the gastroprotective activity of P. pellucid...
S-EPMC6269875 | biostudies-literature
UnknownAnnona cherimola Miller and Its Flavonoids, an Important Source of Products for the Treatment of Diabetes Mellitus: In Vivo and In Silico Evaluations.
The antihyperglycemic activity of ethanolic extract from Annona cherimola Miller (EEAch) and its products were evaluated using in vivo and in silico assays. An α-glucosidase inhibition was evaluated with oral sucrose tolerance tests (OSTT) and molecular docking studies using acarbose as the c...
S-EPMC10222912 | biostudies-literature
UnknownComparison of Lateral Flow Immunochromatography and Phenotypic Assays to PCR for the Detection of Carbapenemase-Producing Gram-Negative Bacteria, a Multicenter Experience in Mexico.
The identification of carbapenemase-producing Enterobacterales and Pseudomonas aeruginosa is important for treating and controlling hospital infections. The recommended methods for their identification require a long waiting time, technical training, and expertise. Lateral flow immunoassays s...
S-EPMC9855030 | biostudies-literature
UnknownAqueous Extracts and Flavonoids Obtained from <i>Annona cherimola</i> Miller as Antidiabetic Treatments Alone and in Combination with Antidiabetic Drugs: In Vivo and In Silico Studies.
Background:Annona cherimola Miller (A. cherimola) is traditionally used in Mexico to treat diabetes. Objectives: this study aimed to evaluate the antihyperglycemic activity of the aqueous leaf extracts (AEAcL) and stem (AEAcS) of A. cherimola alone and combined wit...
S-EPMC12655703 | biostudies-literature
UnknownDiagnostic accuracy cohort study and clinical value of the Histoplasma urine antigen (ALPHA Histoplasma EIA) for disseminated histoplasmosis among HIV infected patients: A multicenter study.

Background

The Histoplasma urine antigen (HUAg) is the preferred method to diagnose progressive disseminated histoplasmosis (PDH) in HIV patients. In 2007, IMMY ALPHA Histoplasma EIA was approved for clinical for on-site use, and therefore useful for regions outside the United States. Howeve...
S-EPMC6237426 | biostudies-literature
UnknownDiagnostic accuracy of antigen detection in urine and molecular assays testing in different clinical samples for the diagnosis of progressive disseminated histoplasmosis in patients living with HIV/AIDS: A prospective multicenter study in Mexico.

Background

The progressive disseminated histoplasmosis (PDH) has been associated with severe disease and high risk of death among people living with HIV (PLWHIV). Therefore, the purpose of this multicenter, prospective, double-blinded study done in ten Mexican hospitals was to determine the ...
S-EPMC7971897 | biostudies-literature
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