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ProteomicsInvasion strategy of pathogenic bacteria is reinforced by a MARTX toxin effector duet
Multiple bacterial genera take advantage of the multifunctional utoprocessing repeats-in-toxin (MARTX) toxin to invade host cells1. Secretion of the MARTX toxin by Vibrio vulnificus, a deadly opportunistic pathogen that causes primary septicemia, the precursor of sepsis2-5, is a major driver of inf...
ORGANISM(S): Homo sapiens (Human) 
2024-07-05 | PXD047927 | Pride
Martx toxin 
GenomicsVibrio vulnificus MARTX toxin effector domains differentially remodel the transcriptional response of intestinal epithelial cells
Vibrio vulnificus MARTX toxin effector domains differentially remodel the transcriptional response of intestinal epithelial cells
PRJNA781942 | ENA
TranscriptomicsVibrio vulnificus MARTX toxin effector domains differentially remodel the transcriptional response of intestinal epithelial cells
Vibrio vulnificus is an foodborne pathogen that can cause gastroenteritis and septicemia in humans. V. vulnificus secretes a multifunctional autoprocessing repeats-in-toxin (MARTX) toxin as an essential virulence factor to cause disease. MARTX toxins are pore-forming toxins that translocate multiple...
ORGANISM(S): Homo sapiens 
2021-11-21 | GSE189194 | GEO
GenomicsDirect cytotoxicity to host cells by the MARTX toxin underlies the hypervirulence of foodborne Vibrio vulnificus
Direct cytotoxicity to host cells by the MARTX toxin underlies the hypervirulence of foodborne Vibrio vulnificus
PRJNA1329186 | ENA
TranscriptomicsDirect cytotoxicity to host cells by the MARTX toxin underlies the hypervirulence of foodborne Vibrio vulnificus
Vibrio vulnificus causes severe necrotizing wound infections and life-threatening foodborne infections. While clinical isolates of V. vulnificus are well-established as human pathogens, the pathogenic mechanisms underlying the virulence of food-derived isolates, particularly in the case of wound inf...
ORGANISM(S): Mus musculus 
2025-09-22 | GSE308195 | GEO
UnknownThe Modes of Action of MARTX Toxin Effector Domains.
Not available
S-EPMC6315884 | biostudies-literature
UnknownMARTX Toxin-Stimulated Interplay between Human Cells and Vibrio vulnificus.
Not available
S-EPMC7426173 | biostudies-literature
UnknownDomain organization and evolution of multifunctional autoprocessing repeats-in-toxin (MARTX) toxin in Vibrio vulnificus.
Not available
S-EPMC3020528 | biostudies-literature
UnknownMultifunctional-autoprocessing repeats-in-toxin (MARTX) Toxins of Vibrios.
Not available
S-EPMC4509488 | biostudies-literature
TranscriptomicsRNA-sequencing analysis examining how the Vibrio cholerae MARTX toxin and its inidividual effector domains modulate the transcriptome of human intestinal epithelial cells.
MARTX toxins are large single polypeptide bacterial toxins that translocate multiple cytotoxic and functionally independent effector domains into the cytosol of a target eukaryotic cell. Pandemic Vibrio cholerae El Tor O1 strains secrete a MARTX toxin with three effector domains — the actin crosslin...
ORGANISM(S): Homo sapiens 
2019-01-23 | GSE125453 | GEO
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