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TranscriptomicsAffymetrix SNP array data for myelodysplastic syndromes (MDS) and related neoplasms
In this study, to obtain a complete registry of genetic lesions in MDS and to identify novel therapeutic targets, we performed SNP array analysis and whole exome analysis for novel mutations using high-throughput sequencing technologies. In whole exome analysis, paired CD3-positive T cells were used...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-31174 | biostudies-arrayexpress
TranscriptomicsExpression analysis of mutant U2AF35 transduced cells
In this study, to obtain the biological impact of the mutated U2AF35, HeLa and TF-1 cells were retrovirally transduced with either mock, wild-type or S34F mutant of U2AF35, and Expression array was performed. Expression analysis was performed for mock, wild-type U2AF35 or S34F mutant transduced HeLa...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-31172 | biostudies-arrayexpress
TranscriptomicsExon level expression profiling of mutant U2AF35 transduced HeLa cells
In this study, to obtain the biological impact of the mutated U2AF35, HeLa cells were retrovirally transduced with either mock, wild-type or S34F mutant of U2AF35, and Exon array was performed. Exon level analysis was performed for mock, wild-type U2AF35 or S34F mutant transduced HeLa in triplicate.
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-31171 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS)
We recently identified recurrent mutations of cohesin complex in myeloid neoplasms through whole-exome sequencing analysis. In this study, we performed SNP array analysis to detect abnormal copy number of the cohesin genes. Copy number analysis by Affymetrix 50K or 250K SNP arrays was performed for ...
ORGANISM(S): Homo sapiens 
2013-07-16 | E-GEOD-47682 | biostudies-arrayexpress
TranscriptomicsComprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
Acute promyelocytic leukemia (APL) is a subtype of myeloid leukemia characterized by differentiation block at the promyelocyte stage. Besides the presence of chromosomal rearrangement t(15;17) leading to formation of PML-RARA fusion, other genetic alterations have also been implicated in APL. ...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-77946 | biostudies-arrayexpress
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