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TranscriptomicsPolysome-associated mRNA profiling of cancer cells in response to CXCL12 and IGF1
CXCL12 and IGF1 are key secreting molecules produced by cancer-associated fibroblasts in breast cancer. These factors promote the survival of disseminated cancer cells in the bone marrow. To assess the combined responses elicited by CXCL12 and IGF1, we examined the translating transcriptome of cance...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-43296 | biostudies-arrayexpress
GenomicsTranscriptomic and Epigenetic analysis of cell line derivatives from H2087 and HCC1954 cell lines
We profiled the transcriptomes of latency-competent cells derived from the human cancer cell lines H2087 (lung adenocarcinoma) and HCC1954 (breast adenocarcinoma) in mitogen-rich and mitogen-low media (MRM and MLM, respectively). In addition, we analyzed the epigenetic landscape of these cell lines ...
ORGANISM(S): Homo sapiens 
2016-03-29 | E-GEOD-72956 | biostudies-arrayexpress
TranscriptomicsTranslating transcriptome of cancer cells in situ in mesenchymal-rich tumor microenvironment
A mesenchymal rich stroma such as cancer-associated fibroblasts (CAFs) in breast tumors favors the selection of cancer clones with enhanced bone metastatic ability. To determine the cancer cell transcriptomic response to the mesenchymal stroma, we supplemented experimental mammary tumours with or wi...
ORGANISM(S): Homo sapiens 
2013-11-01 | E-GEOD-43306 | biostudies-arrayexpress
TranscriptomicsSmad4 and Trim33 dependend nodal/activin responsive genes in differentiated mouse ESCs
In differentiated mouse ESCs, most of the nodal/activin responsive genes are dependent on both Smad4 and Trim33, some are solely dependent on Smad4, and some are dependent on Trim33. Ebs at Day2.5 from WT, Smad4 null, and Trim33 knock-down ESCs, were treated with activin or SB 431542 for 2 h.
ORGANISM(S): Mus musculus 
2012-01-09 | E-GEOD-32903 | biostudies-arrayexpress
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