Sort   by:  
 Page size 
TranscriptomicsGenome-wide expression analysis of the effects of a parasitic nematode's secreted exosomes on mammalian cells.
We show that a gastrointestinal nematode that infects mice, Heligmosomoides polygyrus, secretes vesicles packaged with specific microRNAs (miRNAs) and Y RNAs as well as a nematode-specific Argonaute protein. The vesicles are of intestinal origin and are enriched for homologs of mammalian proteins fo...
ORGANISM(S): Mus musculus 
2014-12-24 | E-GEOD-55941 | biostudies-arrayexpress
TranscriptomicsMetabolic switching of the PII protein GlnK in Streptomyces coelicolor
GlnK is an important nitrogen sensor protein in Streptomyces coelicolor. Deletion of glnK results in a medium-dependent failure of aerial mycelium and spore formation and loss of antibiotic production. Thus, GlnK is not only a regulator of nitrogen metabolism but also of morphological differentiatio...
ORGANISM(S): Streptomyces coelicolor 
2011-12-31 | E-GEOD-30570 | biostudies-arrayexpress
TranscriptomicsMetabolic switching in Streptomyces coelicolor wild type, time series under glutamate depletion condition
During the lifetime of a fermenter culture, the soil bacterium S. coelicolor undergoes a major metabolic switch from exponential growth to antibiotic production. We have studied gene expression patterns during this switch, using a specifically designed Affymetrix GeneChip and a high-resolution time-...
ORGANISM(S): Streptomyces coelicolor 
2011-12-31 | E-GEOD-30569 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of prostate cancer cell line PC-3 ectopically expressing miR-34c to identify genes regulated by this microRNA
In this study we set out to characterize the mechanisms by which miR-34c deregulation contribute to PCa progression. The genes regulated by miR-34c in the prostate cancer cell line PC3 were identified by microarray analyses, and the top biofunctional pathways enriched for identified genes were found...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-41322 | biostudies-arrayexpress
TranscriptomicsExpression profile of sweat gland label retaining cells (LRCs)
We have used the slow cycling property, found in hair follicle stem cells, to look for LRCs in sweat glands as putative stem cells. Gene expression profiling allowed us to determine the common and unique genes expressed in SG LRCs and non-LRCs. This allowed us to probe for the signaling pathways act...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-49011 | biostudies-arrayexpress
GenomicsGenome-wide maps of nucleosome occupancy in human lymphoblastoid cell lines
Nucleosomes are important for gene regulation because their arrangement on the genome can control which proteins bind to DNA. Currently, few human nucleosomes are thought to be consistently positioned across cells; however, this has been difficult to assess due to the limited resolution of existing ...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-36979 | biostudies-arrayexpress
TranscriptomicsSeminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines (methylation data).
Background: Germ Cell Cancers (GCC), originating from Primordial Germ Cells /gonocytes, are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS, stem cell component: embryonal carcinoma (EC)). Somatic mutations are rarely found in GCC. It has been proposed that disr...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56382 | biostudies-arrayexpress
TranscriptomicsSeminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines (gene expression data).
Background: Germ Cell Cancers (GCC), originating from Primordial Germ Cells /gonocytes, are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS, stem cell component: embryonal carcinoma (EC)). Somatic mutations are rarely found in GCC. It has been proposed that disr...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56381 | biostudies-arrayexpress
TranscriptomicsHighly Pathogenic Avian Influenza Viruses Avoid Effective Inflammatory Response of Human Macrophages
Macrophages were infected with low (PR8) and high pathogenic influenza viruses (FPV and H5N1). To our surprise a genome-wide comparative systems biology approach revealed that in contrast PR8 infections with HPAIV H5N1 and FPV result in a reduced immune response of human macrophages contradicting a ...
ORGANISM(S): Homo sapiens 
2012-05-28 | E-GEOD-27702 | biostudies-arrayexpress
TranscriptomicsProgrammed fluctuations in sense/anti-sense transcript ratios drive sexual differentiation in Schizosaccharomyces pombe
Strand specific RNA sequencing of S. pombe revealed a highly structured programme of ncRNA expression at over 600 loci. Waves of antisense transcription accompanied sexual differentiation. A substantial proportion of ncRNA arose from mechanisms previously considered to be largely artefactual, includ...
ORGANISM(S): Schizosaccharomyces pombe 
2011-12-20 | E-GEOD-28113 | biostudies-arrayexpress
Sort   by:  
 Page size