Sort   by:  
 Page size 
TranscriptomicsStem cell factor programs the mast cell activation phenotype
Mast cells, activated by antigen via the high affinity receptor for IgE (FcεRI), release an array of pro-inflammatory mediators that contribute to allergic disorders such as asthma and anaphylaxis. The KIT ligand, stem cell factor (SCF), is critical for mast cell expansion, differentiation and survi...
ORGANISM(S): Mus musculus 
2012-05-01 | E-GEOD-35332 | biostudies-arrayexpress
TranscriptomicsMAZR and mast cells
Mast cells are known to be the key players in type I hypersensitivity reactions in humans and mice. They are critically involved in the development of allergic rhinitis, allergic asthma and systemic anaphylaxis. In this study we investigated the role of the transcriptional regulator MAZR in mast cel...
ORGANISM(S): Mus musculus 
2013-10-18 | E-MTAB-1816 | biostudies-arrayexpress
TranscriptomicsTwo functionally distinct subsets of mast cells generated through IL-2 independent CD25 activities
CD25 (IL-2R) can be expressed on the surface of immune cells in the absence of other chains of the interleukin-2 receptor (IL-2R), which are indispensable for IL-2 signaling. We identified two novel mast cell subsets, characterized by the differential expression of surface CD25, and by the ability t...
ORGANISM(S): Mus musculus 
2014-08-03 | E-GEOD-52502 | biostudies-arrayexpress
ProteomicsMouse connective tissue mast cell proteome
Mast cells are hematopoietic cells that reside preferentially in tissues exposed to internal and external environments. Mast cells sense immunological, inflammatory and environmental stimuli, and can be activated to release granules and generate inflammatory mediators. Mast cell-derived products con...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-12 | PXD015040 | Pride
Mouse Peritoneal mast cell Mast cell 
TranscriptomicsGlobal gene expression analysis of canine cutaneous mast cell tumor
In the present study, canine mast cell tumor (MCT) transcriptome was characterized in order to identify a set of candidate genes potentially useful for MCT classification and prognosis prediction. Fifty-one canine MCT biopsies were enrolled in the study. Isolated and purified total RNAs were individ...
ORGANISM(S): Canis lupus familiaris 
2014-05-06 | E-GEOD-50433 | biostudies-arrayexpress
TranscriptomicsExpression data from HMC-1 mast cells
We demonstrate that the G protein Gi3 is the cellular target of the adenosine A3 receptor (A3R). By using a cell permeable peptide comprising the C-terminal end of Gαi3 fused to an importation sequence (ALL1) as a selective inhibitor of Gi3 signaling, we show that by coupling to Gi3, the A3R stimu...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-19888 | biostudies-arrayexpress
TranscriptomicsMast cell microRNAs regulated by KIT signaling
Objective is to identify microRNAs regulated by KIT signaling in mast cells. miRNA profiles of murine bone marrow derived mast cells with and without SCF treatment were compared. In addition, miRNA profiles of the P815 mutant KIT cell line with and without the KIT inhibitor, imatinib, were compare...
ORGANISM(S): Mus musculus 
2011-01-25 | E-GEOD-26783 | biostudies-arrayexpress
ProteomicsHuman connective tissue mast cell proteome
Mast cells are hematopoietic cells that reside preferentially in tissues exposed to internal and external environments. Mast cells sense immunological, inflammatory and environmental stimuli, and can be activated to release granules and generate inflammatory mediators. Mast cell-derived products con...
ORGANISM(S): Homo sapiens (Human) 
2020-02-12 | PXD014978 | Pride
Human Fat mast cell Skin mast cell 
TranscriptomicsMast cell expression data from murine aryl hydrocarbon receptor (AhR) null, AhR_d and normal control mice
We found that AhR, a unique chemical sensor, is critical in controlling mast cell differentiation, growth and function in vitro and in vivo. This study seeks to further the understanding of the mechanisms of how AhR control mast cell homeostasis. Three different batches of bone marrow derived mast c...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-44715 | biostudies-arrayexpress
TranscriptomicsIL-33 induces a hypo-responsive human mast cell phenotype
Interleukin-33 (IL-33) is elevated in afflicted tissues of patients with mast cell-dependent chronic allergic diseases. Based on its acute effects on mouse mast cells (MCs), IL-33 is thought to play a role in the pathogenesis of allergic disease through MC activation. However, the manifestations of ...
ORGANISM(S): Mus musculus 
2013-02-06 | E-GEOD-39382 | biostudies-arrayexpress
Sort   by:  
 Page size