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MetabolomicsEffect of Genetically Reduced Maternal Myostatin on Late Gestation Maternal, Fetal, and Placental Metabolomes in Mice.
Myostatin (gene symbol: Mstn) is an autocrine and paracrine inhibitor of muscle growth. Pregnant mice with genetically reduced levels of myostatin give birth to offspring with greater adult muscle mass and bone biomechanical strength. However, maternal myostatin is not detectable in fetal cir...
2023-06-08 | MTBLS3345 | MetaboLights
MetabolomicsSexual dimorphism in the fetal cardiac response to maternal nutrient restriction
Poor maternal nutrition causes intrauterine growth restriction (IUGR); however, its effects on fetal cardiac development are unclear. We have developed a baboon model of moderate maternal undernutrition, leading to IUGR. We hypothesized that the IUGR affects fetal cardiac structure and metabolism. S...
2018-04-30 | MTBLS426 | MetaboLights
MetabolomicsPregnancy-Induced Metabolic Phenotype Variations in Maternal Plasma
Metabolic variations occur during normal pregnancy to provide the growing fetus with a supply of nutrients required for its development and to ensure the health of the woman during gestation. Mass spectrometry-based metabolomics was employed to study the metabolic phenotype variations in the materna...
2015-03-03 | MTBLS146 | MetaboLights
MetabolomicsMaternal Gut Microbiota Influences Immune Activation at the Maternal-Fetal Interface Affecting Pregnancy Outcome

Preeclampsia is a leading cause of morbidity and mortality in pregnant women, affecting 5-8% of gestations worldwide. Its development is influenced by maternal immune abnormalities, metabolic disorders and gut dysbiosis. In this study, we show that gut dysbiosis in pregnant C57BL/6J dams leads to...

2025-05-07 | MTBLS12316 | MetaboLights
MetabolomicsMetabolic profiling of maternal serum of women at high-risk of spontaneous preterm birth using NMR and MGWAS approach
Preterm birth (PTB) is a leading global cause of infant mortality. Risk factors include genetics, lifestyle choices and infection. Understanding the mechanism of PTB could aid the development of novel approaches to prevent PTB. This study aimed to investigate the metabolic biomarkers of PTB in early...
2023-05-24 | MTBLS1990 | MetaboLights
MetabolomicsMetabolomic Profiling and Trajectories During Gestation: Associations with Maternal and Child Health

The metabolic regulations during pregnancy are precisely programmed, even small deviations can bring devastating consequences. Here, we constructed a comprehensive view of the metabolome trajectories throughout pregnancy in 9,687 plasma samples from 3,339 pregnant women, including 2,348 naturally...

2026-06-27 | MTBLS10849 | MetaboLights
TranscriptomicsGene expression changes in the septum: possible implications for microRNAs in sculpting the maternal brain.
The transition from the non-maternal to the maternal state is characterized by a variety of CNS alterations that support the care of offspring. The septum (including lateral and medial portions) is a brain region previously linked to various emotional and motivational processes, including maternal c...
ORGANISM(S): Mus musculus 
2012-08-22 | E-GEOD-30836 | biostudies-arrayexpress
TranscriptomicsGene expression profile in offspring born before vs. after maternal bariatric surgery
Evaluate differences in gene expression levels between offspring born after maternal bariatric surgery and their siblings born before surgery Offspring born after maternal bariatric surgery (AMS, N=23) vs. offspring born before maternal surgery (BMS, N=23)
ORGANISM(S): Homo sapiens 
2013-05-16 | E-GEOD-44407 | biostudies-arrayexpress
MetabolomicsLimited vertical transmission but profound immune dysregulation at the maternal-fetal interface after SARS-CoV-2 infection

The endemic of SARS-CoV-2 underscores the imperative to elucidate its effects on pregnancy, particularly regarding the potential for vertical transmission and its influence on the early maternal-fetal interface, which remain insufficiently defined. To address this, we performed an extensive cohor...

2026-03-05 | MTBLS13103 | MetaboLights
MetabolomicsMaternal chromium propionate reprograms the gut-blood-placenta axis to support neonatal immune and metabolic development in dairy calves: a multi-omics insight

This study sequenced the non-target metabolome of maternal plasma samples from dairy cows to investigate the effect of chromium propionate supplementation on maternal plasma metabolism in the pre-peripartum period.

2025-07-09 | MTBLS12696 | MetaboLights
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