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MetabolomicsEffect of Genetically Reduced Maternal Myostatin on Late Gestation Maternal, Fetal, and Placental Metabolomes in Mice.
Myostatin (gene symbol: Mstn) is an autocrine and paracrine inhibitor of muscle growth. Pregnant mice with genetically reduced levels of myostatin give birth to offspring with greater adult muscle mass and bone biomechanical strength. However, maternal myostatin is not detectable in fetal cir...
2023-06-08 | MTBLS3345 | MetaboLights
MetabolomicsMetabolic profiling of maternal serum of women at high-risk of spontaneous preterm birth using NMR and MGWAS approach
Preterm birth (PTB) is a leading global cause of infant mortality. Risk factors include genetics, lifestyle choices and infection. Understanding the mechanism of PTB could aid the development of novel approaches to prevent PTB. This study aimed to investigate the metabolic biomarkers of PTB in early...
2023-05-24 | MTBLS1990 | MetaboLights
MetabolomicsMaternal Gut Microbiota Influences Immune Activation at the Maternal-Fetal Interface Affecting Pregnancy Outcome

Preeclampsia is a leading cause of morbidity and mortality in pregnant women, affecting 5-8% of gestations worldwide. Its development is influenced by maternal immune abnormalities, metabolic disorders and gut dysbiosis. In this study, we show that gut dysbiosis in pregnant C57BL/6J dams leads to...

2025-05-07 | MTBLS12316 | MetaboLights
MetabolomicsFaecalibaculum rodentium as a key player in combating maternal obesity-induced labor disorders

The global rise in maternal obesity increases the risk of adverse maternal and neonatal outcomes. This study demonstrates that both long- (12 weeks) and short-term (gestational) exposure to a high-fat diet (HFD) induces uterine labor disorders, elevates stillbirth rates, and alters gut microbiota...

2025-08-22 | MTBLS12877 | MetaboLights
MetabolomicsComparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach

The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early development of the gut microbiota. Fecal samples from 20...

2024-03-07 | MTBLS7670 | MetaboLights
MetabolomicsMaternal steroids during pregnancy and their associations with ambient air pollution and temperature during preconception and early gestational periods
Hormones play critical roles in facilitating pregnancy progression and the onset of parturition. Several classes of environmental contaminants, including fine particulate matter (PM2.5) and ambient temperature, have been shown to alter hormone biosynthesis or activity. However, epidemiolo...
2024-06-27 | MTBLS2245 | MetaboLights
MetabolomicsMaternal MASLD rewires milk bile-acid hydrophobicity to restrict microbiome-dependent neonatal ketone supply_hippocampus
Maternal metabolic dysfunction-associated steatotic liver disease (MASLD) in mice creates a paradoxical neonatal ketone deficit during nursing, despite preserved hepatic ketogenesis, that precedes adult spatial memory impairment. Vulnerable litters show reduced β-hydroxybutyrate (β-HB) in the intest...
2026-08-02 | MTBLS15224 | MetaboLights
MetabolomicsGut Microbiome and Serum Metabolic Alterations in Recurrent Gestational Diabetes Mellitus

Gestational diabetes mellitus (GDM) is a common complication of pregnancy, particularly affecting multiparous women with a history of GDM, who face a recurrence risk approaching 50%. This study investigates the association between gut microbiota modifications and metabolic profiles from early to ...

2025-07-21 | MTBLS12326 | MetaboLights
MetabolomicsMetabolomics Study of Serum and Urine Samples Reveals Metabolic Pathways and Biomarkers Associated with Pelvic Organ Prolapse
Pelvic organ prolapse (POP) is a common medical condition among women and involves complicated diagnostics and controversial surgical management. The exact molecular mechanism underlying POP is poorly understood, especially at the metabolism level. To explore the metabolic mechanism underlying POP a...
2019-08-14 | MTBLS1033 | MetaboLights
MetabolomicsMaternal MASLD rewires milk bile-acid hydrophobicity to restrict microbiome-dependent neonatal ketone supply_milk

Maternal metabolic dysfunction-associated steatotic liver disease (MASLD) in mice creates a paradoxical neonatal ketone deficit during nursing, despite preserved hepatic ketogenesis, that precedes adult spatial memory impairment. Vulnerable litters show reduced β-hydroxybutyrate (β-HB) in the int...

2026-08-02 | MTBLS15225 | MetaboLights
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