Sort   by:  
 Page size 
TranscriptomicsGene expression analysis in liver collected from mice administered non-toxic, toxic, or severely toxic LNA sequences
Development of LNA gapmers, antisense oligonucleotides used for efficient inhibition of target RNA expression, is limited by non-target mediated hepatotoxicity issues. In the present study, we investigated hepatic transcription profiles of mice receiving non-toxic and toxic LNA gapmers after a singl...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-53230 | biostudies-arrayexpress
ProteomicsTargeted MS assay to evaluate Cereblon neosubstrate changes in rabbit embryos following maternal administration of IMiDs
Targeted protein degradation is the selective removal of a protein of interest through hijacking intracellular protein cleanup machinery. This rapidly growing field currently relies heavily on the use of the E3 ligase Cereblon (CRBN) to target proteins for degradation, including the immunomodulatory...
ORGANISM(S): Oryctolagus Cuniculus 
PXD050568 | panorama
Sort   by:  
 Page size