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TranscriptomicsMicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors (discovery)
Liposarcomas are rare, heterogeneous and malignant tumors that can be divided into five histological subtypes with different characteristics and clinical behavior. Treatment consists of surgery in combination with systemic chemotherapy, but nevertheless mortality rates are high. More insight into th...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-45359 | biostudies-arrayexpress
TranscriptomicsmiR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway
The development of drug resistance is still a major impediment for the successful treatment of cancer, such as advanced stage ovarian cancer, which has a 5-year survival rate of only 30%. The molecular processes that contribute to resistance have been extensively studied, however, not much is known ...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-54665 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors (validation)
Liposarcomas are rare, heterogeneous and malignant tumors that can be divided into five histological subtypes with different characteristics and clinical behavior. Treatment consists of surgery in combination with systemic chemotherapy, but nevertheless mortality rates are high. More insight into th...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-45363 | biostudies-arrayexpress
TranscriptomicsDNA damage responsive microRNAs misexpressed in human cancer regulate chemotherapy sensitivity (lung cancer cell lines)
The DNA damage response (DDR) is a cellular process that protects the genetic information against DNA damage and inhibits malignant transformation. Tumor cells are characterized by an aberrant DDR, which is exploited by genotoxic chemotherapy. However, cancer cells are able to develop drug resistan...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-47524 | biostudies-arrayexpress
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