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GenomicsRequired Enhancer: Matrin-3 Structure Interactions for Homeodomain Transcription Programs
Study of the POU-homeodomain transcription factor, has revealed that, binding of Pit1-occupied enhancers to a nuclear matrin-3-rich network/architecture is a key event in effective activation of the Pit1-regulated enhancer / coding gene transcriptional program. All ChIP-seq(s) were designed to under...
ORGANISM(S): Rattus norvegicus 
2014-08-03 | E-GEOD-58009 | biostudies-arrayexpress
ProteomicsALS Associated Mutations in Matrin 3 Alter Protein-Protein Interactions and Impede mRNA Nuclear Export
Mutations in Matrin 3 have recently been linked to ALS, though the mechanism of disease in these patients is still unknown. To define the protein interactome of wild-type and ALS-linked MATR3 mutations, we performed immunoprecipitation followed by mass spectrometry experiments in NSC-34 cells expres...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-15 | PXD007710 | Pride
Als Lc/ms-ms Trex Matrin-3 
TranscriptomicsTranscription profiling of HeLa cells expressing GFP-tagged chicken matrin 3
We have found that exogenous expression of matrin 3 in chicken DT40 cells and human HeLa cells suppressed expression of endogenous matrin 3 at mRNA level. To find other genes showing decreased expression by exogenous matrin 3, gene expression profiles of wild-type HeLa cells and HeLa cells expressi...
ORGANISM(S): Homo sapiens 
2007-03-10 | E-MEXP-1032 | biostudies-arrayexpress
ProteomicsProtein interaction networks for Matrin 3 encoding mutations
To understand how mutations in Matrin 3 (MATR3) cause amyotrophic lateral sclerosis (ALS) and distal myopathy, we used transcriptome and interactome analysis. We found over-expression of wild-type (WT) or F115C mutant MATR3 had little impact on gene expression in neuroglia cells. We identified ~123 ...
ORGANISM(S): Homo sapiens (Human) 
2018-08-03 | PXD008896 | Pride
Matrin 3 Interaction 
UnknownNuclear matrix protein Matrin 3 is a regulator of ZAP-mediated retroviral restriction.
Not available
S-EPMC4487854 | biostudies-literature
UnknownHeterogeneity of Matrin 3 in the developing and aging murine central nervous system.
Not available
S-EPMC5832027 | biostudies-literature
UnknownDisruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations.
Not available
S-EPMC4492393 | biostudies-literature
GenomicsLiver-specific matrin-3 knockout alters the hepatic transcriptome of chow diet-fed mice [RNA-seq]
Liver-specific matrin-3 knockout alters the hepatic transcriptome of chow diet-fed mice [RNA-seq]
PRJNA1110273 | ENA
GenomicsLiver-specific matrin-3 knockout alters the hepatic transcriptome of high-fat diet-fed mice [RNA-seq]
Liver-specific matrin-3 knockout alters the hepatic transcriptome of high-fat diet-fed mice [RNA-seq]
PRJNA1034150 | ENA
GenomicsLiver-specific matrin-3 knockout alters the chromatin accessibility in the liver of mice [ATAC-seq]
Liver-specific matrin-3 knockout alters the chromatin accessibility in the liver of mice [ATAC-seq]
PRJNA1034146 | ENA
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