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TranscriptomicsProteolytic inactivation of the autoinhibitory prodomain is essential for the pro-tumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP)
Invasive cancers employ pericellular proteolysis to breach the extracellular matrix and basement membrane barriers and invade the surrounding tissue. Pro-invasive, pro-tumorigenic MT1-MMP is the primary mediator of proteolytic events on the cancer cell surface. Cellular MT1-MMP is synthesized as a l...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28655 | biostudies-arrayexpress
TranscriptomicsEpidermal cells help coordinate leukocyte migration during inflammation through fatty acid-fueled matrix metalloproteinase production
In addition to satisfying the metabolic demands of cells, mitochondrial metabolism helps regulate immune cell function. To date, such cell-intrinsic metabolic-immunologic cross-talk has only been described operating in cells of the immune system. Here we show that epidermal cells utilize fatty acid ...
ORGANISM(S): Danio rerio 
2014-04-01 | E-GEOD-56365 | biostudies-arrayexpress
TranscriptomicsUpregulation of Expression of Matrix Metalloproteinases in Alveolar Macrophages of HIV1+ Smokers with Early Emphysema
HIV1+ smokers develop emphysema at an earlier age and with a higher incidence than HIV1- smokers. Based on the knowledge that human alveolar macrophages (AM) are capable of producing proteases that degrade extracellular matrix components, we hypothesized that upregulation of AM matrix metalloprotein...
ORGANISM(S): Homo sapiens 
2016-03-24 | E-GEOD-10038 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity
Previously we have shown that extravillous cytotrophoblast (EVT) outgrowth and migration on a collagen gel explant model were restricted by exposure to decidual natural killer cells (dNK). This study investigates the molecular causes behind this phenomenon. Genome wide DNA methylation of exposed and...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-60885 | biostudies-arrayexpress
TranscriptomicsWhole genome expression signature of SWCNT and MWCNT vs. asbestos subchronic exposures to human pleural mesothelial cells
Malignant mesothelioma is one of the most aggressive forms of cancer known. Recent studies have shown that carbon nanotubes (CNTs) are biopersistent and induce mesothelioma in animals, but the underlying mechanisms are not known. Here, we investigate the effect of long-term exposure to CNTs on the a...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-48855 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse C57Bl6 MMP-7 and MMP-10 deficient mice Pseudomonas aeruginosa exposed airway epithelium.
Airway epithelium is the initial point of host-pathogen interaction in Pseudomonas aeruginosa infection, an important pathogen in cystic fibrosis and nosocomial pneumonia. We used global gene expression analysis to determine airway epithelial transcriptional responses dependent on matrilysin (MMP-7)...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7957 | biostudies-arrayexpress
UnknownNovel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging.
Not available
S-EPMC7054845 | biostudies-literature
UnknownEffect of World Trade Center Dust Exposure and Chronic Intermittent Hypoxia on Macrophage Matrix Metalloproteinase-12 Expression in Mice
Not available
S-EPMC5955033 | biostudies-literature
UnknownMatrix Metalloproteinase-12 Is Required for Granuloma Progression.
Not available
S-EPMC7531023 | biostudies-literature
UnknownEnhanced expression of matrix metalloproteinase-12 contributes to Npc1 deficiency-induced axonal degeneration.
Not available
S-EPMC4446199 | biostudies-literature
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