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MetabolomicsThe Impacts of Sortase A and the 4'-Phosphopantetheinyl Transferase Homolog Sfp on Streptococcus mutans Extracellular Membrane Vesicle Biogenesis

Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is incomplete. We used single gene deletions to evaluate the impacts on Streptococcus mutans EMV biogenesis of Sortase A (SrtA), which affects S. mutans...

2021-10-06 | MTBLS1812 | MetaboLights
TranscriptomicsGPM6B regulates osteoblast differentiation and induction of mineralization by controlling cytoskeleton and matrix vesicle release.
Analysis of GPM6B silenced osteogenic hMSC at gene expression level. Analysis is showing significant changes in genes involved in cytoskeleton organization and biogenesis. Immunocytochemistry confirms changed distribution of actin filaments and change in shape and in size of focal adhesions upon GP...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-26004 | biostudies-arrayexpress
MetabolomicsNorgestrel exposure accelerated the abnormal occurrence of germinal vesicle breakdown and triggered damage to cellular structure and function in oocytes of the Pacific oyster (Crassostrea gigas)

Progestins are ubiquitous in aquatic environments, with adverse effects on aquatic organisms' reproduction even at extremely low concentrations (0.8 ng/L). As female germ cells, oocytes play an irreplaceable role in organismal reproductive processes. However, the toxic mechanism of norgestrel (NG...

2025-09-10 | MTBLS12976 | MetaboLights
ProteomicsWDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling
The endosomal FYVE- and WD40-domain-containing protein WDFY2 has been assigned a function as tumor suppressor, but its functional mechanism has remained elusive. Here we have used confocal, widefield and super-resolution fluorescence microscopy to show that WDFY2 localizes to the base of retromer-co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-23 | MSV000084122 | MassIVE
UnknownBiomimetic mineralization using matrix vesicle nanofragments.
Not available
S-EPMC6594056 | biostudies-literature
ProteomicsAntifungal turbinmicin alters functional vesicle cargo
Extracellular vesicle delivery in Candida biofilms is important for matrix delivery and associated drug-resistance. Prior study found the antifungal turbinmicin inhibits vesicle release. We find the antifungal turbinmicin inhibits both vesicle release as well as cargo loading. Using comparative vesi...
ORGANISM(S): Candida albicans (Yeast) 
2026-04-06 | PXD076431 | Pride
Turbinmicin Proteomics Candida Extracellular vesicles 
ProteomicsGolgin knockouts alter extracellular matrix secretion
The secretion of extracellular matrix (ECM) proteins is vital to the maintenance of tissue health. One 28 major control point of this process is the Golgi apparatus, whose dysfunction causes numerous 29 connective tissue disorders. Golgi function is tightly linked to its structure, which is maintain...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD061302 | Pride
Secretion Extracellular matrix Golgin 
UnknownActivin A suppresses osteoblast mineralization capacity by altering extracellular matrix (ECM) composition and impairing matrix vesicle (MV) production.
Not available
S-EPMC3790298 | biostudies-literature
ProteomicsCoordination of fungal biofilm development by extracellular vesicle cargo
The fungal pathogen Candida albicans can form biofilms that protect it from drugs and the immune system. The biofilm cells release extracellular vesicles (EVs) that promote extracellular matrix formation and resistance to antifungal drugs. Here, we define functions for numerous EV cargo proteins in ...
ORGANISM(S): Candida albicans (Yeast) 
2022-02-16 | PXD028596 | Pride
Candida albicans Extracellular vesicles Matrix proteomics Biofilm Biofilms 
ProteomicsSynaptic vesicle proteomics with age and in synucleinopathies
Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein’s function and dysfunction in Parkinson’s disease and other synucleinopathies is tightly linked to synaptic vesicle binding. Age is the biggest risk factor for synucleinopathy, and ~15% of synaptic vesicle proteins ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-02 | PXD048771 | Pride
Synuclein Synaptic vesicle Mouse Age 
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