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TranscriptomicsTransformation of elongation factor 1Bdelta into heat shock response transcription factor by alternative splicing
Protein translation factors play crucial roles in a variety of stress responses. Here, we show that the eukaryotic elongation factor 1Bdelta (eEF1Bdelta) changes its structure and function from a translation factor into a heat shock response transcription factor by alternative splicing. While eEF1Bd...
ORGANISM(S): Homo sapiens 
2011-04-12 | E-GEOD-28506 | biostudies-arrayexpress
Transcriptomicshuman Nalm6 Cells: WT vs. OGFOD1 KO
The 2-OG-Fe(II) dioxygenase family are critical for cellular adaptation to changes in oxygen concentration. We found that cells with OGFOD1 gene silencing in this family showed resistance to cell death under ischemia, and cDNA microarray analysis of OGFOD1 knockout human cells revealed downregulatio...
ORGANISM(S): Homo sapiens 
2010-04-29 | E-GEOD-21557 | biostudies-arrayexpress
TranscriptomicsMolecular strategy for survival at a critical high temperature in Eschierichia coli
To investigate the effect for organisms by the treatment of the critical high remperature (CHT), we use Escherichia coli as a model organism and performed the transcriptome analysis to compare the genome wide transcriptional profiles between under the treatment of normal temperature, 37 degree C and...
ORGANISM(S): Escherichia coli 
2011-04-30 | E-MEXP-3191 | biostudies-arrayexpress
TranscriptomicsThe induced APL cells generated by the transplantation of PML-RARA-transduced human CD34+ hematopoietic cells into immunodeficient mice
A humanized in vivo APL model has been established utilizing the retroviral transduction of PML-RARA into human CD34+ hematopoietic cells and the transplantation of these cells into immunodeficient mice. The resultant leukemia recapitulated human APL phenotypically, and was clustered in the same cat...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-49344 | biostudies-arrayexpress
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