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MetabolomicsMetabonomic analysis of human and 12 kinds of livestock mature milk

Mature milk, as a nutrient-rich endogenous metabolite, has various beneficial effects on the human body. In order to investigate the specific nutrients provided by different dairy products to humans, we used UHPLC-Q-TOF MS to analyze the highly significantly differentially expressed metabolites i...

2023-08-21 | MTBLS6777 | MetaboLights
MetabolomicsLipid profile analysis of donkey milk during the lactation

Background: From ancient times, donkey milk (DM) has attracted much attention due to its particular properties. Donkey milk is characterized by a high level of lactose and low levels of protein and fat. However, studies investigating lipid changes in donkey milk during lactation are limited....

2025-09-06 | MTBLS12948 | MetaboLights
MetabolomicsMaternal MASLD rewires milk bile-acid hydrophobicity to restrict microbiome-dependent neonatal ketone supply_milk

Maternal metabolic dysfunction-associated steatotic liver disease (MASLD) in mice creates a paradoxical neonatal ketone deficit during nursing, despite preserved hepatic ketogenesis, that precedes adult spatial memory impairment. Vulnerable litters show reduced β-hydroxybutyrate (β-HB) in the int...

2026-08-02 | MTBLS15225 | MetaboLights
MetabolomicsAnalysis of lipid nutrient differences in the milk of 13 species from a quantitative non-targeted lipidomics perspective

Lipid, an important organic component in milk, has health benefits for newborns. Profiles of milk lipid in multi-species from multi-level haven’t been accessible, therefore, we established a lipid subclass, lipid molecule, and fatty acid profile of 13 species to compare interspecific lipid differ...

2023-08-21 | MTBLS6767 | MetaboLights
TranscriptomicsRNA-sequencing of the human milk fat layer during colostrum, transitional, and mature stages of lactation
Human milk fat globules, by enveloping cell contents during their secretion into milk, are a rich source of mammary cell RNA. Here, we pair this non-invasive mRNA source with RNA sequencing technology to probe the milk fat layer transcriptome during three stages of lactation: colostral, transitional...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-45669 | biostudies-arrayexpress
MetabolomicsHuman milk as infantile Super Food - the effect of dietary choices and supplementation on the shift of lipidomic profile during different stages of lactation
The objective of this project was to establish an advanced analytical method leveraging high-resolution mass spectrometry LC-HRMS to comprehensively profile the human milk lipidome. Mass spectrometry resolves and quantifies compounds based on a fundamental physical metric: the mass-to-charge ratio. ...
2026-09-22 | MTBLS15678 | MetaboLights
TranscriptomicsTime dependent expression profiles of mRNAs in rat milk
We have reported that mRNAs are present in bovine milk. But, it is unknown the roles of milk mRNAs. To clarify the roles of milk mRNAs, experimental animal such as rat study would be needed. However, it is unclear whether rat milk also contains mRNAs. Thus, we have employed microarray to show that r...
ORGANISM(S): Rattus norvegicus 
2014-02-18 | E-GEOD-44112 | biostudies-arrayexpress
TranscriptomicsTime dependent expression profiles of microRNAs in rat milk
We have reported that microRNAs are present in human and bovine milk. But, it is unknown the roles of milk miRNAs. To clarify the roles of milk miRNAs, experimental animal such as rat study would be needed. However, it is unclear whether rat milk also contains miRNAs. Thus, we have employed microarr...
ORGANISM(S): Rattus norvegicus 
2014-02-18 | E-GEOD-44113 | biostudies-arrayexpress
ProteomicsProteomic Profiling of Donkey Milk Exosomes Highlights Bioactive Proteins with Immune-Related Functions
Proteomic profiles of exosomes isolated from donkey colostrum and mature milk using advanced four-dimensional (4D) label-free quantitative proteomics. A comprehensive analysis identified and quantified a total of 2,293 exosomal proteins from donkey milk, including 276 differentially expressed exosom...
ORGANISM(S): Equus Asinus X Caballus 
2025-03-18 | PXD061958 |
ProteomicsComparative Proteomic Analysis of Extracellular Vesicles from Donkey Colostrum and Mature Milk
Donkey milk (DM) has been considered a valuable alternative to human and bovine coun-terparts as well as to infant formulas. Milk extracellular vesicles (EVs) have been proposed to influence key biological processes. The purpose of this study is to provide a compre-hensive characterization of the p...
ORGANISM(S): Equus asinus (Donkey) 
2025-10-06 | PXD067848 | Pride
Proteomics Donkey milk Extracellular vesicles Colostrum Molecular cargo 
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