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TranscriptomicsMicroRNAs may indirectly regulate other microRNAs
MicroRNAs (miRNAs) are a class of regulatory RNAs that control the expression of genes critical to cell function. Ectopic expression of miRNAs has been shown to result in genome-wide changes in patterns of gene expression. While the reasons for these global alterations in gene expression patterns ha...
ORGANISM(S): Homo sapiens 
2012-04-08 | E-GEOD-29129 | biostudies-arrayexpress
TranscriptomicsmiRNAs in ovarian cancer: A systems approach (MAS5, plier, GCRMA)
MicroRNAs (miRNAs) are short (~22 nucleotides) regulatory RNAs that can modulate gene expression and are aberrantly expressed in many diseases including cancer. Previous studies have shown that miRNAs inhibit the translation and facilitate the degradation of their targeted mRNAs making them attracti...
ORGANISM(S): Homo sapiens 
2011-07-28 | E-GEOD-27431 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profile of pre-transfected HEY cells
MicroRNAs (miRNAs) are short (~22 nucleotides) regulatory RNAs that can modulate gene expression and are aberrantly expressed in many diseases including cancer. We wanted to quantify the levels of endogenous miRNAs in pre-transfected HEY ovarian cancer cells to identify the highly expressed miRNAs. ...
ORGANISM(S): Homo sapiens 
2012-04-08 | E-GEOD-29126 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling provides evidence of the existence of two functionally distinct classes of ovarian cancer stroma
RNA microarray profiling of 45 tissue samples was carried out using the Affymetrix (U133) gene expression platform. Laser capture microdissection (LCM) was employed to isolate cancer cells from the tumors of 18 serous ovarian cancer patients (Cepi). For 7 of these patients, a matched set of surround...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-38666 | biostudies-arrayexpress
TranscriptomicsmiRNAs in ovarian cancer: A systems approach (mRNA data)
MicroRNAs (miRNAs) are short (~22 nucleotides) regulatory RNAs that can modulate gene expression and are aberrantly expressed in many diseases including cancer. We report the results of a systems analysis of miRNA regulation in ovarian cancer. We found that 33 miRNAs are up-regulated and 9 down-regu...
ORGANISM(S): Homo sapiens 
2011-07-28 | E-GEOD-23391 | biostudies-arrayexpress
TranscriptomicsInflammation and Extracellular Matrix Genes Differentially Expressed Following Overlapping Zotarolimus- and Sirolimus-Eluting Stent Implantation
An unanticipated complication of the use of bare metal stents in percutaneous transluminal coronary angioplasty is in-stent restenosis resulting in >50% late lumen diameter loss in treated patients. In an effort to reduce in-stent restenosis, drug eluting stents containing the immunosuppressant sir...
ORGANISM(S): Sus scrofa 
2011-04-22 | E-GEOD-28781 | biostudies-arrayexpress
TranscriptomicsmiRNAs in ovarian cancer: A systems approach (miRNA data)
MicroRNAs (miRNAs) are short (~22 nucleotides) regulatory RNAs that can modulate gene expression and are aberrantly expressed in many diseases including cancer. We report the results of a systems analysis of miRNA regulation in ovarian cancer. We found that 33 miRNAs are up-regulated and 9 down-regu...
ORGANISM(S): Homo sapiens 
2011-07-28 | E-GEOD-23383 | biostudies-arrayexpress
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