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TranscriptomicsGenome-wide RNAi screen identifies miR-19 targets in Notch-induced acute T-cell leukaemia (T-ALL)
MicroRNAs (miRNAs) have emerged as novel cancer genes. In particular, the 17~92 cluster of miRNAs is highly expressed in haematopoietic cancers and promotes lymphomagenesis in vivo1,2. Clinical use of these findings hinges on isolating the oncogenic activity within the 17~92 cluster and defining its...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-20097 | biostudies-arrayexpress
TranscriptomicsRNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A/DDX2 RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of Silvestrol and related compounds. For example, eIF4A promo...
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-56887 | biostudies-arrayexpress
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