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ProteomicsTrypanosomal Pam18/Pam16 and maxicircle replication – TbPam18 SILAC RNAiTrypanosomal Pam18/Pam16 and maxicircle replication – TbPam18 SILAC RNAi
Protein import and genome replication are essential processes for mitochondrial biogenesis and propagation. The J-domain proteins Pam16 and Pam18 regulate the presequence translocase of the mitochondrial inner membrane. In the protozoan Trypanosoma brucei, their counterparts are TbPam16 and TbPam18,...
ORGANISM(S): Trypanosoma brucei 
2024-07-20 | PXD046845 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome replication Silac Maxicircle replication Rnai-mediated protein knockdown 
ProteomicsTrypanosomal Pam18/Pam16 and maxicircle replication – TbPam16 CoIPs
Protein import and genome replication are essential processes for mitochondrial biogenesis and propagation. The J-domain proteins Pam16 and Pam18 regulate the presequence translocase of the mitochondrial inner membrane. In the protozoan Trypanosoma brucei, their counterparts are TbPam16 and TbPam18,...
ORGANISM(S): Trypanosoma brucei 
2024-07-20 | PXD046849 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome replication Affinity purification-mass spectrometry Silac Maxicircle replication 
ProteomicsTrypanosomal Pam18/Pam16 and maxicircle replication – MaRF11 SILAC RNAi
Protein import and genome replication are essential processes for mitochondrial biogenesis and propagation. The J-domain proteins Pam16 and Pam18 regulate the presequence translocase of the mitochondrial inner membrane. In the protozoan Trypanosoma brucei, their counterparts are TbPam16 and TbPam18,...
ORGANISM(S): Trypanosoma brucei 
2024-07-20 | PXD053251 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome replication Silac Maxicircle replication Rnai-mediated protein knockdown 
ProteomicsTrypanosomal Pam18/Pam16 and maxicircle replication – TbPam16 SILAC RNAi
Protein import and genome replication are essential processes for mitochondrial biogenesis and propagation. The J-domain proteins Pam16 and Pam18 regulate the presequence translocase of the mitochondrial inner membrane. In the protozoan Trypanosoma brucei, their counterparts are TbPam16 and TbPam18,...
ORGANISM(S): Trypanosoma brucei 
2024-07-20 | PXD046840 | Pride
Trypanosoma brucei Proteomics Mitochondrial genome replication Silac Maxicircle replication Rnai-mediated protein knockdown 
UnknownTrypanosomes have six mitochondrial DNA helicases with one controlling kinetoplast maxicircle replication.
Not available
S-EPMC2763077 | biostudies-literature
TranscriptomicsmtTF1: A Novel Factor Involved in Mitochondrial Gene Expression in Trypanosoma brucei
Mitochondrial DNA replication and gene expression are essential for cell survival. In Trypanosoma brucei, a protozoan animal and human parasite, the mitochondrial RNA polymerase (mtRNAP) plays roles in both transcription and DNA replication. This study identifies and characterizes the first mitochon...
ORGANISM(S): Trypanosoma brucei 
2025-05-26 | GSE297664 | GEO
UnknownPam16 and Pam18 were repurposed during Trypanosoma brucei evolution to regulate the replication of mitochondrial DNA.
Not available
S-EPMC11349236 | biostudies-literature
UnknownThe kinetoplast duplication cycle in Trypanosoma brucei is orchestrated by cytoskeleton-mediated cell morphogenesis.
Not available
S-EPMC3067821 | biostudies-literature
UnknownTrypanosoma cruzi mitochondrial maxicircles display species- and strain-specific variation and a conserved element in the non-coding region.
Not available
S-EPMC1559615 | biostudies-literature
UnknownThe Complete Mitochondrial DNA of Trypanosoma cruzi: Maxicircles and Minicircles.
Not available
S-EPMC8277381 | biostudies-literature
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