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MetabolomicsComparative Metabolomic Sampling of Upper and Lower Airways by Four Different Methods to Identify Biochemicals That May Support Bacterial Growth
Bacteria need nutrients from the host environment to survive, yet we know little about which biochemicals are present in the airways (the metabolome), which of these biochemicals are essential for bacterial growth and how they change with airway disease. The aims of this pilot study were to develop ...
2019-06-13 | MTBLS179 | MetaboLights
MetabolomicsMetabolic analysis of the response of Pseudomonas putida DOT-T1E strains to toluene using Fourier transform infrared spectroscopy and gas chromatography mass spectrometry
To elucidate any observable metabolic alterations during interactions of several strains of Pseudomonas putida (DOT-T1E, and its mutants DOT-T1E-PS28 and DOT-T1E-18) with the aromatic hydrocarbon toluene, metabolomic approaches were employed. Initially, Fourier-transform infrared (FT-IR) spectroscop...
2016-08-23 | MTBLS319 | MetaboLights
TranscriptomicsExpression data from stimulated or unstimulated human CD4+ T cells incubated with edelfosine
The cytotoxic drug edelfosine is a synthetic analog of 2-lysophosphatidylcholine. Edelfosine is incorporated by highly proliferating cells, e.g. activated immune cells. It is unknown if the described mechanisms for edelfosine action attained by in vitro approaches exclusively contribute to the obser...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-44392 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human FoxP3+CD4+CD25+high regulatory T cells (Tregs) isolated from recent-onset type 1 diabetes mellitus (T1D) patients and controls
Naturally occurring FoxP3+CD4+CD25+high regulatory T cells (Tregs) play an important role in dominant tolerance, suppressing auto-reactive CD4+CD25- T cell activity. Although Tregs from T1D subjects are functionally deficient, there is little knowledge of the molecular mechanisms that orchestrate th...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-10586 | biostudies-arrayexpress
TranscriptomicsEvaluation of the Affymetrix Brassica Exon 1.0 ST array
The aim of the experiment was to evaluate the performance of the Affymetrix Brassica Exon 1.0 ST array. Root and leaf samples from Brassica rapa line R-O-18 were compared. The same RNA samples were hybridised to the Agilent Brassica array, to compare the performance of the two arrays. 6 samples were...
ORGANISM(S): Brassica rapa 
2010-09-10 | E-GEOD-23141 | biostudies-arrayexpress
MetabolomicsTargeted metabolomic profiling of myocardial remodeling after STEMI

Early detection of myocardial remodeling is essential for optimizing outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, reliable biomarkers for predicting STEMI myocardial remodeling remain scarce.

Targeted metabolomic profiling was performed on plasma ...

2025-09-02 | MTBLS10634 | MetaboLights
TranscriptomicsA Validated Gene Signature from Peripheral Blood Mononuclear Cells in Pulmonary Hypertension Associated with Sickle Cell Disease
Pulmonary hypertension (PH) is a serious complication of sickle cell disease (SCD) associated with increased mortality. Gene expression profiles of peripheral blood mononuclear cells (PBMC) have been studied in pulmonary arterial hypertension and in SCD. We hypothesized that a PBMC-derived gene sign...
ORGANISM(S): Homo sapiens 
2012-06-06 | E-GEOD-38528 | biostudies-arrayexpress
TranscriptomicsWhole-genome microarray analysis of primary, secondary, tertiary and quaternary memory CD8 T cells
The transcriptome of naive OT-I T cells was compared to memory CD8 T cells after 1, 2, 3, or 4 infection with ovalbumin expressing Listeria monocytogenes (LM-OVA). Naive Thy1.1 OT-I T cells were adoptively transferred into Thy1.2 naive hosts prior to infection with LM-OVA. The resulting memory CD8 T...
ORGANISM(S): Mus musculus 
2010-07-09 | E-GEOD-21360 | biostudies-arrayexpress
TranscriptomicsExpression data from OT-I CD8 T cells activated with DC in the presence or absence of CpG-Induced Inflammation
Inflammatory cytokines promote the accumulation of activated CD8 T cells. Here, we transfer 600 OT-I CD8 T cells iv into naïve C57BL/6 hosts. One day later, 500,000 LPS-matured and OVA257 peptide-coated DC were injected iv into OT-I CD8 T cell seeded hosts with (DC+CpG) or without (DC). Other se...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-53200 | biostudies-arrayexpress
TranscriptomicsTranscriptome and Molecular Pathways Analysis of CD4 T-Cells from Young NOD Mice
Type 1 diabetes is a multigenic disease caused by T-cell mediated destruction of the insulin producing β-cells. Although conventional (targeted) approaches of identifying causative genes have advanced our knowledge of this disease, many questions remain unanswered. Using a whole molecular systems st...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-46600 | biostudies-arrayexpress
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