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ProteomicsDissecting the molecular effects of cigarette smoke on proteasome function
Proteasome dysfunction is emerging as a novel pathomechanism for the development of chronic obstructive pulmonary disease (COPD), a major leading cause of death in the world. Cigarette smoke is one of the main risk factors for COPD and has been shown to impair proteasome function in vitro and in viv...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2019-01-08 | PXD007148 | Pride
Cigarette smoke Proteasome 
ProteomicsCigarette smoke alters the secretome of lung epithelial cells
Cigarette smoke is the most relevant risk factor for the development of lung cancer and chronic obstructive pulmonary disease. Many of its more than 4500 chemicals are highly reactive, thereby altering protein structure and function. Here, we used subcellular fractionation coupled to label-free quan...
ORGANISM(S): Homo sapiens (Human) 
2019-01-08 | PXD007180 | Pride
Lung Proteomic profiling Cigarette smoke Secretome 
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