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UnknownBright and stable luminescent probes for target engagement profiling in live cells.
Not available
S-EPMC8555866 | biostudies-literature
UnknownA direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader.
Not available
S-EPMC9391279 | biostudies-literature
UnknownStructural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly.
Not available
S-EPMC10564622 | biostudies-literature
TranscriptomicsHDAC6 and HSP90 control the functions of Foxp3+ T regulatory cells
Foxp3+ T-regulatory cells (Tregs) are key to immune homeostasis such that their diminished numbers or function can cause autoimmunity and allograft rejection. Foxp3+ Tregs express histone/protein deacetylases (HDACs) that regulate chromatin remodeling, gene expression and protein function. Pan-HDAC ...
ORGANISM(S): Mus musculus 
2011-05-01 | E-GEOD-27896 | biostudies-arrayexpress
UnknownThe cyclimids: Degron-inspired cereblon binders for targeted protein degradation.
Not available
S-EPMC12136240 | biostudies-literature
UnknownElucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.
Not available
S-EPMC9403976 | biostudies-literature
GenomicsActivation of the Integrated Stress Response by a Jumonji Histone Demethylase Inhibitor Induces Pro-Apoptotic Metabolic Reprogramming in Multiple Myeloma
Regulation of gene expression by chromatin modification through methylation of histone lysine residues is a dynamic, reversible process that when deregulated is associated with cancer development. In multiple myeloma, combined inhibition of the histone demethylases JARID1B, UTX and JmjD3 by the smal...
ORGANISM(S): Homo sapiens 
2015-08-21 | E-GEOD-60626 | biostudies-arrayexpress
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