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ProteomicsStandardized workflow for precise mid- and high-throughput proteomics of blood biofluids
Background: Accurate discovery assay workflows are critical for identifying authentic circulating protein biomarkers in diverse blood matrices. Maximizing the commonalities in the proteomic workflows between different biofluids simplifies the approach and increases the likelihood for reproducibility...
ORGANISM(S): Homo Sapiens 
2022-05-11 | PXD024884 | panorama
ProteomicsGlobal Hyper-Phosphorylation Characterizes Liver Disease Progression in Methionine Adenosyltransferase 1A Knockout Mice
Methionine adenosyltransferase 1a (Mat1a) is responsible for hepatic biosynthesis of S-adenosyl-L-methionine (SAMe), the principal cellular methyl donor. Mat1a -/- mice have decreased hepatic SAMe levels, and spontaneously develop nonalcoholic steatohepatitis (NASH) which can be reversed with exogen...
ORGANISM(S): Homo Sapiens Mus Musculus 
2026-06-12 | PXD022122 | panorama
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