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TranscriptomicsExpression data from cyclically stretched engineered neonatal rat ventricuar myocyte (NRVM) tissues
Mechanical overload in the heart induces pathological remodeling that typcially leads to heart failure. We sought to build an in vitro model of heart failure by applying cyclic stretch to engineered isotropic (iso) and anisotropic (aniso) NRVM tissues. We used micoarrays to determine the effects of ...
ORGANISM(S): Rattus norvegicus 
2013-01-30 | E-GEOD-43846 | biostudies-arrayexpress
ProteomicsDistinct phenotypes induced by acute hypoxia and TGF-β1 in human adult cardiac fibroblasts
Myocardial infarctions cause hypoxic injury to downstream tissue and a consequent fibrotic remodeling process to replace injured tissue with a scar. Scar formation occurs through phases of wound healing in which stimuli such as transforming growth factor-beta (TGF-β) drive cardiac fibroblasts to act...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD051197 | Pride
Hypoxia Transforming growth factor-beta Cardiac fibrosis Hypoxia-inducible factors Myocardial infarction 
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