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TranscriptomicsTrans. Profiling of Immortalized Melanocyte Cell Lines Identifies GPNMB as a Melanoblast-Expressed, MITF-Dependent Gene
Gene expression profiling of tissues derived from different genetic backgrounds can provide insight to potential phenotype-related changes in gene expression. We have compared wildtype C57BL/6 (melan-Ink4a) melanocyte cell gene expression to that of, “brown“ Tyrp1b/ b (melan-Ink4a-b) and “cho...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-10163 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cell line mESC D3 reveals cardiac differentiation of embryonic stem cells recapitulates embryonic cardiac development.
Mouse embryonic stem cells can differentiate in vitro into spontaneously contracting cardiomyocytes. The main objective of this study was to investigate cardiogenesis in cultures of differentiating embryonic stem cells (ESCs) and to determine how closely it mimics in vivo cardiac development. We ide...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5671 | biostudies-arrayexpress
GenomicsGenetic analysis of Hirschsprung disease

Hirschsprung disease (HSCR) is a birth defect resulting from the absence of nerve (ganglion) cells in the gastrointestinal tract. Hirschsprung disease has a population incidence of 1/5,000 live births and most often occurs as an isolated condition. However, approximately 30% of HSCR cases are ass...

phs000497.v1.p1 | EGA
GenomicsChIP-seq for EP300 and H3K4me1 in the mouse melanocyte cell line melan-a
Using ChIP-seq for p300 and H3K4me1, we identified 2,489 putative melanocyte enhancer loci in the mouse genome. We demonstrated that these putative enhancers are evolutionarily constrained, enriched for sequence motifs predicted to bind key melanocyte transcription factors, located near genes releva...
ORGANISM(S): Mus musculus 
2012-09-14 | E-GEOD-38498 | biostudies-arrayexpress
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