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TranscriptomicsFunctional Plasticity of Regulatory T Cell Function
Regulatory T cells (Tregs) can suppress a wide variety of cell types, in diverse organ sites and inflammatory conditions. While Tregs possess multiple suppressive mechanisms, the number required for maximal function is unclear. Furthermore, whether any inter-relationship orcross-regulatory mechani...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29262 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of seven consecutive stages of mouse thymocyte development
Expression profiles of seven consecutive stages of mouse thymocyte development were generated.
ORGANISM(S): Mus musculus 
2007-12-20 | E-GEOD-272 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of T-lymphoblastic leukemia of childhood [gene expression]
The purpose of this study was the principal investigation and frequency of RTK expression in primary T-ALLs. Primary initial T-ALLs were assessed regarding their transcriptome-wide expression profiles and screend for prominent RTK expression. Naive primary T-ALL samples were evaluated with regard t...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-42038 | biostudies-arrayexpress
UnknownInosine Monophosphate Dehydrogenase Pharmacogenetics in Hematopoietic Cell Transplantation Patients.
Not available
S-EPMC6414227 | biostudies-literature
TranscriptomicsGene expression profiling of rat jejunum treated with MLT-943, a small molecule MALT1 protease inhibitor
MALT1 protease inhibition is effective in several preclinical models of autoimmunity and B cell malignancies. However, severe reduction in regulatory T cells (Tregs) and an associated IPEX-like pathology was observed in mice with congenital deficiency of MALT1. Rats treated with MLT-943, a novel pot...
ORGANISM(S): Rattus norvegicus 
2020-04-30 | E-MTAB-8990 | biostudies-arrayexpress
TranscriptomicsNatalizumab exerts direct signaling capacity and supports a pro-inflammatory phenotype in some patients with multiple sclerosis
Natalizumab is a recombinant monoclonal antibody raised against integrin alpha-4 (CD49d). It is approved for the treatment of patients with multiple sclerosis (MS), a chronic inflammatory autoimmune disease of the CNS. Natalizumab blocks leukocyte extravasation across the blood-brain barrier by inhi...
ORGANISM(S): Homo sapiens 
2015-05-02 | E-GEOD-37783 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis to identify Tween 20 inducible genes
Polyethylene glycol sorbitan monoacylates (Tween) are detergents of widespread use in plant sciences. We show them, notably Tween 20, to cause a rapid and complex change in transcript abundance which bears all characteristics of a PAMP / elicitor-induced defense response, and they do so at concentra...
ORGANISM(S): Arabidopsis thaliana 
2009-11-10 | E-GEOD-5513 | biostudies-arrayexpress
TranscriptomicsUpregulation of immunoproteasome subunits in myositis indicates active inflammation with involvement of antigen presenting cells, CD8 T-cells and IFNM-NM-3
Objective: In idiopathic inflammatory myopathies (IIM) infiltration of immune cells into muscle and upregulation of MHC-I expression implies increased antigen presentation and involvement of the proteasome system. To decipher the role of immunoproteasomes in myositis, we investigated individual cell...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-58173 | biostudies-arrayexpress
TranscriptomicsNFATc1 controls the survival, function and suppressive capacity of B lymphocytes upon B cell receptor stimulation
Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ ...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-21063 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans late larvae and adult developmental stages treated with low-intensity microwave irradiation reveals no substantial alteration in gene expression
Reports that low-intensity microwave radiation can induce heat-shock reporter gene expression in the nematode, Caenorhabditis elegans, have recently been reinterpreted as a subtle thermal effect caused by very slight heating. This study used a microwave exposure system (1.0 GHz, 0.5 W power input; ...
ORGANISM(S): Caenorhabditis elegans 
2009-03-20 | E-GEOD-10787 | biostudies-arrayexpress
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