Sort   by:  
 Page size 
UnknownUsing brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
Genetics have nominated many schizophrenia risk genes and identified convergent signals between schizophrenia and neurodevelopmental disorders. However, functional interpretation of the nominated genes in the relevant brain cell types is often lacking. We executed interaction proteomics for six schi...
S-EPMC10189495 | biostudies-literature
UnknownDistinct genetic liability profiles define clinically relevant patient strata across common diseases.
Stratified medicine holds great promise to tailor treatment to the needs of individual patients. While genetics holds great potential to aid patient stratification, it remains a major challenge to operationalize complex genetic risk factor profiles to deconstruct clinical heterogeneity. Contemporary...
S-EPMC11217418 | biostudies-literature
UnknownEstimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.
Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score regression (LDSC) and genomic restricted maximum likelihood (GREML). The massively ...
S-EPMC5993419 | biostudies-literature
UnknownLD Score regression distinguishes confounding from polygenicity in genome-wide association studies.
Both polygenicity (many small genetic effects) and confounding biases, such as cryptic relatedness and population stratification, can yield an inflated distribution of test statistics in genome-wide association studies (GWAS). However, current methods cannot distinguish between inflation from a true...
S-EPMC4495769 | biostudies-literature
UnknownAge at first birth in women is genetically associated with increased risk of schizophrenia.
Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth...
S-EPMC6033923 | biostudies-literature
UnknownGenome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness.
Genome-wide association studies (GWAS) of schizophrenia have yielded more than 100 common susceptibility variants, and strongly support a substantial polygenic contribution of a large number of small allelic effects. It has been hypothesized that familial schizophrenia is largely a consequence of in...
S-EPMC5816590 | biostudies-literature
UnknownGenetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genom...
S-EPMC4852730 | biostudies-literature
UnknownPartitioning heritability of regulatory and cell-type-specific variants across 11 common diseases.
Regulatory and coding variants are known to be enriched with associations identified by genome-wide association studies (GWASs) of complex disease, but their contributions to trait heritability are currently unknown. We applied variance-component methods to imputed genotype data for 11 common diseas...
S-EPMC4225595 | biostudies-literature
UnknownContrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis.
Heritability analyses of genome-wide association study (GWAS) cohorts have yielded important insights into complex disease architecture, and increasing sample sizes hold the promise of further discoveries. Here we analyze the genetic architectures of schizophrenia in 49,806 samples from the PGC and ...
S-EPMC4666835 | biostudies-literature
UnknownSchizophrenia risk from complex variation of complement component 4.
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia's strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular mechanisms accounting for this have been challenging ...
S-EPMC4752392 | biostudies-literature
Sort   by:  
 Page size