Sort   by:  
 Page size 
TranscriptomicsChronic low dose-rate versus acute ionizing radiation induced gene expression in primary derived prostate fibroblasts
Using a novel flood source construct, we performed a direct comparison of genome-wide gene expression regulations resulting from exposure of primary human prostate fibroblast cultures to acute (10cGy and 200cGy) and longer-term chronic (1.0-2.45cGy cumulative over 24hr) exposures. Samples were colle...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-52918 | biostudies-arrayexpress
MetabolomicsDistinct metabolic responses of an ovarian cancer stem cell line

Background

Cancer metabolism is emerging as an important focus area in cancer research. However, the in vitro cell culture conditions under which much cellular metabolism research is performed differ drastically from in vivo tumor conditions, which are characterized by variations in the leve...
2021-11-05 | MTBLS150 | MetaboLights
TranscriptomicsGenome-scale epigenetic reprogramming during epithelial to mesenchymal transition
Epithelial to mesenchymal transition (EMT) is an extreme example of cell plasticity, important for normal development, injury repair, and malignant progression. Widespread epigenetic reprogramming occurs during stem cell differentiation and malignant transformation, but EMT-related epigenetic reprog...
ORGANISM(S): Mus musculus 
2011-07-03 | E-GEOD-28291 | biostudies-arrayexpress
MetabolomicsOVCAR-3 spheroid-derived cells display distinct metabolic profiles
Recently, multicellular spheroids were isolated from a well-established epithelial ovarian cancer cell line, OVCAR-3, and were propagated in vitro. These spheroid derived cells displayed numerous hallmarks of cancer stem cells, which are chemo and radioresistant cells thought to be a significant cau...
2015-01-08 | MTBLS152 | MetaboLights
UnknownWhip Rule Breaches in a Major Australian Racing Jurisdiction: Welfare and Regulatory Implications.
Not available
S-EPMC5295154 | biostudies-literature
MetabolomicsMetabolic Dynamics in Escherichia coli-Based Cell-Free Systems
The field of metabolic engineering has yielded remarkable accomplishments in using cells to produce valuable molecules, and cell-free expression (CFE) systems have the potential to push the field even further. However, CFE systems still face some outstanding challenges, including endogenous metaboli...
2023-02-22 | MTBLS2630 | MetaboLights
ProteomicsIdentification of Helicobacter pylori LolD
We engineered a derivative of H. pylori strain 26695 that expresses an N-terminal DDK-tagged version of LolF from the endogenous locus. As controls, we also engineered strains to express DDK-tagged versions of two unrelated inner membrane proteins ExbD2 and FrdC. The tagged proteins were affinity pu...
ORGANISM(S): Helicobacter Pylori 26695 (ncbitaxon:85962) 
2023-01-31 | MSV000091176 | MassIVE
MetabolomicsMetabolic Profiling of Escherichia coli-Based Cell-Free Expression Systems for Process Optimization
Biotechnology has transformed the production of various chemicals and pharmaceuticals due to its efficient and selective processes, but it is inherently limited by its use of live cells as 'biocatalysts.' Cell-free expression (CFE) systems, which use a protein lysate isolated from whole cells, have ...
2020-06-02 | MTBLS1079 | MetaboLights
TranscriptomicsStereo-sequencing: 3D Transcriptome of the mouse embryo at gastrulation
To glean an appreciation of the holistic genetic activity in the gastrulating mouse embryo, we performed a genome-wide spatial transcriptome analysis (Stereo-seq), using a low-cell number sequencing protocol on laser microdissected samples of epiblast cells with retained positional address. The 3D t...
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-65924 | biostudies-arrayexpress
UnknownPrioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics.
Not available
S-EPMC8196250 | biostudies-literature
Sort   by:  
 Page size