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ProteomicsiPRG 2012: A Study on Detecting Modified Peptides in a Complex Mixture
This is the data and results associated with the 2012 study organized by the proteome informatics research group of the Association of Biomolecular Resource Facilities, which investigated participants' ability to identify a range of post-translationally modified peptides spiked into a yeast lysate b...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2013-11-19 | MSV000078492 | MassIVE
UnknownSenolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

Background

Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases. Senolytics, including the combination of Dasatinib and Quercetin ...
S-EPMC6796530 | biostudies-literature
UnknownMedical management of muscle weakness in Duchenne muscular dystrophy.

Introduction

Duchenne muscular dystrophy (DMD) is a childhood onset muscular dystrophy leading to shortened life expectancy. There are gaps in published DMD care guidelines regarding recently approved DMD medications and alternative steroid dosing regimens.

Methods

A list of statement...
S-EPMC7571693 | biostudies-literature
UnknownDeveloping standardized corticosteroid treatment for Duchenne muscular dystrophy.
Despite corticosteroids being the only treatment documented to improve strength and function in boys with Duchenne muscular dystrophy (DMD) corticosteroid prescription is inconsistent and in some countries, corticosteroids are not prescribed. We are conducting a clinical trial that (1) compares the ...
S-EPMC6279424 | biostudies-literature
GenomicsEstrogen Receptor Positive Breast Cancer: Aromatase Inhibitor Response Study

Highly variable outcomes are observed in patients with estrogen receptor positive (ER+) breast cancer who undergo preoperative estrogen deprivation therapy with aromatase inhibitors (AI). In this study, 46 tumor and normal genomes and 31 exomes of participants selected from two clinical trials of...

phs000472.v1.p1 | EGA
UnknownA checklist for clinical trials in rare disease: obstacles and anticipatory actions-lessons learned from the FOR-DMD trial.

Background

Trials in rare diseases have many challenges, among which are the need to set up multiple sites in different countries to achieve recruitment targets and the divergent landscape of clinical trial regulations in those countries. Over the past years, there have been initiatives to f...
S-EPMC5968578 | biostudies-literature
UnknownEffect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy: A Randomized Clinical Trial.

Importance

Corticosteroids improve strength and function in boys with Duchenne muscular dystrophy. However, there is uncertainty regarding the optimum regimen and dosage.

Objective

To compare efficacy and adverse effects of the 3 most frequently prescribed corticosteroid regimens in b...
S-EPMC8984930 | biostudies-literature
TranscriptomicsSimilarity of PDXs between passages and lineages using Affymetrix mRNA expression data
PDX tumors at various passages post first implantation in nude mice PDX tumors were profiled at different passages when they reached ~400mm3
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-78806 | biostudies-arrayexpress
UnknownEstimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.
Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score regression (LDSC) and genomic restricted maximum likelihood (GREML). The massively ...
S-EPMC5993419 | biostudies-literature
UnknownCharacterization of severe COL6-related dystrophy due to the recurrent variant COL6A1 c.930+189C>T.
Collagen VI-related dystrophies manifest with a spectrum of clinical phenotypes, ranging from Ullrich congenital muscular dystrophy (UCMD), presenting with prominent congenital symptoms and characterized by progressive muscle weakness, joint contractures and respiratory insufficiency, to Bethlem mus...
S-EPMC12404708 | biostudies-literature
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