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GenomicsRNA-RNA interactions enable specific targeting of noncoding RNAs to nascent pre-mRNAs and chromatin sites
We developed a general method based on RNA Antisense Purification (RAP) to identify the intermolecular RNA-RNA interactions of a target RNA (RAP-RNA). RAP-RNA identifies endogenous RNA-RNA complexes through in vivo crosslinking, RNA capture with antisense oligonucleotides, and high-throughput RNA se...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-55914 | biostudies-arrayexpress
GenomicsXist exploits three-dimensional chromosome architecture to spread across the X-chromosome
Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. Here we investigate the localization mechanisms of Xist during X-chromosome inactivation (XCI), a paradigm of lncRNA-mediated chromatin regulation. During the maint...
ORGANISM(S): Mus musculus 
2013-05-30 | E-GEOD-46918 | biostudies-arrayexpress
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