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TranscriptomicsDistinct DNA methylation patterns of cognitive impairment and Trisomy 21 in Down Syndrome
The presence of an extra whole or part of chromosome 21 in people with Down syndrome (DS) is associated with multiple neurological changes, including pathological aging that often meets the criteria for Alzheimer’s Disease (AD). While the mechanism underlying these changes is unknown, it has been hy...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-50586 | biostudies-arrayexpress
ProteomicsStructural basis for DNA recognition and allosteric control of the Retinoic Acid Receptors RAR-RXR
Retinoic Acid Receptors (RARs) as a functional heterodimer with Retinoid X Receptors (RXRs), bind a diverse series of RA-response elements (RAREs) in regulated genes. Among them, the non-canonical DR0 elements are bound by RXR-RAR with comparable affinities to DR5 elements but DR0 elements do not ac...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-10 | PXD018172 | Pride
Hdx Nuclear receptors Structural ms Hdx-ms 
TranscriptomicsDNA methylation profiling in human Huntington's Disease brain
Despite extensive progress in Huntingtonâ??s Disease (HD) research, very little is known about the association of epigenetic variation and HD pathogenesis in human brain tissues. Moreover, its contribution to the tissue-specific transcriptional regulation of the huntingtin gene (HTT), in which HTT e...
ORGANISM(S): Homo sapiens 
2016-03-11 | E-GEOD-79064 | biostudies-arrayexpress
UnknownSARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination.
Not available
S-EPMC9762734 | biostudies-literature
UnknownCo-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study.
Not available
S-EPMC8172149 | biostudies-literature
UnknownNon-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study.
Not available
S-EPMC8104907 | biostudies-literature
UnknownChanges in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK.
Not available
S-EPMC8121531 | biostudies-literature
UnknownImplementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study.
Not available
S-EPMC8940185 | biostudies-literature
UnknownCharacterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study.
Not available
S-EPMC8285118 | biostudies-literature
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