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TranscriptomicsTherapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells
Several viruses can infect the mammalian nervous system and induce neurological dysfunction. Adoptive immunotherapy (AI) is an approach that involves administration of antiviral T cells and has shown promise in clinical studies for the treatment of peripheral virus infections in humans such as cytom...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-66421 | biostudies-arrayexpress
TranscriptomicsOpposing Roles of STAT1 and STAT3 in IL-21 Function in CD4+ T cells
Interleukin-21 (IL-21) is a type 1 cytokine essential for immune cell differentiation and function. Although IL-21 can activate several STAT family transcription factors, previous studies focused mainly on the role of STAT3 in IL-21 signaling. Here, we investigated the role of STAT1 and show that ST...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-63204 | biostudies-arrayexpress
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