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TranscriptomicsExpression values from wild-type retinas and retinas with a mutant Rhodopsin transgene (Tg(RHO P347S)) with and without Endothelin-2 (EDN2)
Expression of the Endothelin-2 (Edn2) mRNA is greatly increased in the photoreceptors (PRs) of mouse models of inherited PR degeneration. To identify retinasl gene whose expression is directly or indirectly regulated by EDN2 in the presence of the Tg(RHO P347S) mutant allele, we defined mRNAs that w...
ORGANISM(S): Mus musculus 
2012-07-15 | E-GEOD-38797 | biostudies-arrayexpress
TranscriptomicsAn IL-1β driven neutrophil-stromal cell axis fosters a BAFF-rich microenvironment in multiple myeloma
Neutrophils are the most abundant nucleated cell type in the bone marrow. A pro-tumor bias in this cell type may have implications for bone-marrow residing malignancies, such as multiple myeloma. Here, we generated single cell transcriptomic overviews of the entire myeloid compartment, including the...
ORGANISM(S): Homo sapiens 
2023-03-31 | E-MTAB-12760 | biostudies-arrayexpress
TranscriptomicsPaired scRNAseq of the and non-hematopoietic and the immune microenvironment of aspirates from newly diagnosed Multiple Myeloma patients versus non-cancer controls
By generating a paired single cell RNA-sequencing database of the tumor niche from 10 newly diagnosed MM patients, we created a unique dataset allowing the in-depth analyses of stromal-immune interactions within the tumor microenvironment. Using this database, we identified the presence of inflammat...
ORGANISM(S): Homo sapiens 
2020-09-30 | E-MTAB-9139 | biostudies-arrayexpress
TranscriptomicsscRNAseq of the bone marrow immune microenvironment in control and 5TGM1 myeloma-bearing C57Bl/6 and KaLwRij mice
We hypothesized that the immune microenvironment of the bone marrow influences the progression of myeloma outgrowth in the 5TGM1 transfer model of multiple myeloma. Therefore we sorted bone marrow T, B, NK, neutrophils, and monocytes/macrophages from control and tumor-bearing C57Bl/6 and KaLwRij mic...
ORGANISM(S): Mus musculus 
2023-02-23 | E-MTAB-12616 | biostudies-arrayexpress
UnknownResidual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury.
Not available
S-EPMC12860639 | biostudies-literature
UnknownDesign innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1.
Not available
S-EPMC3481179 | biostudies-literature
UnknownAdd-On Treatment With Zilebesiran for Inadequately Controlled Hypertension: The KARDIA-2 Randomized Clinical Trial.
Not available
S-EPMC12120674 | biostudies-literature
UnknownGenetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Not available
S-EPMC3142887 | biostudies-literature
UnknownRheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.
Not available
S-EPMC2662493 | biostudies-literature
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