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TranscriptomicsHDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain [DRG tissue]
Histone deacetylase inhibitors (HDACIs) interfere with the epigenetic process of histone acetylation and are known to have analgesic properties in models of chronic inflammatory pain. The aim of this study was to determine whether these compounds could also affect neuropathic pain. Different class I...
ORGANISM(S): Rattus norvegicus 
2013-10-01 | E-GEOD-51295 | biostudies-arrayexpress
TranscriptomicsHDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain [spinal cord tissue]
Histone deacetylase inhibitors (HDACIs) interfere with the epigenetic process of histone acetylation and are known to have analgesic properties in models of chronic inflammatory pain. The aim of this study was to determine whether these compounds could also affect neuropathic pain. Different class I...
ORGANISM(S): Rattus norvegicus 
2013-10-01 | E-GEOD-51294 | biostudies-arrayexpress
GenomicsSubtelomeric p53 Binding Prevents Accumulation of DNA Damage at Human Telomeres
Telomeres and tumor suppressor protein TP53 (p53) function in genome protection, but a direct role of p53 at telomeres has not yet been described. Here, we have identified non-canonical p53 binding sites within the human subtelomeres that suppress the accumulation of DNA damage at telomeric repeat ...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-75528 | biostudies-arrayexpress
TranscriptomicsNociceptor HDAC4 regulates inflammatory pain
Transcriptional alterations are characteristic of persistent pain states but the key regulators remain elusive. Using a conditional knockout (cKO) strategy in mice we sought to determine whether loss of the transcriptional co-repressor histone deacetylase four (HDAC4) would have implications for sen...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-62405 | biostudies-arrayexpress
UnknownMolecular mechanisms underlying the enhanced analgesic effect of oxycodone compared to morphine in chemotherapy-induced neuropathic pain.
Not available
S-EPMC3949760 | biostudies-literature
UnknownEvaluation of Recombinant Botulinum Neurotoxin Type A1 Efficacy in Peripheral Inflammatory Pain in Mice.
Not available
S-EPMC9179158 | biostudies-literature
TranscriptomicsHDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2013-10-01 | E-GEOD-51296 | biostudies-arrayexpress
UnknownHDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain.
Not available
S-EPMC3763368 | biostudies-literature
UnknownPARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration-resistant prostate cancer.
Not available
S-EPMC12936415 | biostudies-literature
UnknownThe National Lung Screening Trial: overview and study design.
Not available
S-EPMC3009383 | biostudies-literature
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