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TranscriptomicsTranscription profiling of human CD8 naive (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells
Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naïve (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells using gene expression microarrays and phospho-protein-specific i...
ORGANISM(S): Homo sapiens 
2005-01-01 | E-TABM-40 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte derived dendritic cells treated with DC-SIGN initiates an immature dendritic cell phenotype triggering Rho activation that is utilised by HIV-1
DC-SIGN is a C-type lectin expressed by dendritic cells (DCs) that binds HIV-1, sequestering it within multivesicular bodies to facilitate transmission to CD4+ T cells. Here we characterize the molecular basis of signalling through DC-SIGN by large-scale gene expression profiling and phosphoproteome...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6090 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4+ memory T cells reveals they are preferential targets for bystander activation and apoptosis
There is much evidence that T cells may be activated via mechanisms which act independently of direct TCR ligation. Despite this, the question of whether such forms of ‘bystander’ T cell activation occur during immune responses is hotly debated. To address some outstanding questions, we set up ...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-13738 | biostudies-arrayexpress
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