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MetabolomicsIsotopomer analysis of MCF-7 breast cancer cell line incubated with 13C labelled glucose (NMR assay)
MS and NMR are two of the most powerful spectroscopic techniques used in the field of fluxomics, to analyze the flux distributions in cellular metabolomic pathways. Both of them possess pros and cons, such as, MS being the most sensitive and low-cost technique, while needs extensive sample processin...
2018-05-02 | MTBLS241 | MetaboLights
MetabolomicsIsotopomer analysis of MCF-7 breast cancer cell line incubated with 13C labelled glucose (GC-MS assay)
MS and NMR are two of the most powerful spectroscopic techniques used in the field of fluxomics, to analyze the flux distributions in cellular metabolomic pathways. Both of them possess pros and cons, such as, MS being the most sensitive and low-cost technique, while needs extensive sample processin...
2018-05-02 | MTBLS182 | MetaboLights
MetabolomicsThe effects of oligomycin administration and glutamine deprivation on metabolic profile of MCF7 breast cancer cell line measured using [1,2-13C2]-D-glucose and [U-13C5]-L-glutamine as tracers
This study aims to establish a comprehensive, genome-scale metabolic model (GSMM) combining different omics data of different regulatory levels of breast cancer cells in order to elucidate the way that these regulatory levels affect or determine each other. Together with transcriptomics, proteomics ...
2021-01-18 | MTBLS183 | MetaboLights
MetabolomicsBiological Effects of Amphiphilic Copolymer Nanoparticle-Encapsulated Multi-target Chemotherapeutic Drugs on MCF-7 Human Breast Cancer Cells
INTRODUCTION: Amphiphilic copolymer nanoparticle-encapsulated multi-target chemotherapeutic drugs have attracted considerable attention due to their favorable drug efficiency and potential application prospect. Studies have shown that an amphiphilic copolymer, methoxypoly(ethylene glycol)-poly(lacti...
2018-05-03 | MTBLS430 | MetaboLights
MetabolomicsThe Poly (ADP-Ribose) Polymerase inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells
Breast tumors are characterized into different subtypes based on their surface marker expression, which affects their prognosis and treatment. For example, triple negative breast cancer cells (ER-/PR-/Her2-) show reduced susceptibility towards radiotherapy and chemotherapeutic agents. Poly (ADP-ribo...
2016-11-07 | MTBLS337 | MetaboLights
TranscriptomicssiRNA profiling if human MCF-7 cell line to investigate the role of FAK, dominant-negative FAK, FAK-CD and FAKsiRNA in MCF-7 human breast cancer cell tumorigenesis
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays an important role in proliferation, motility, adhesion, invasion, angiogenesis, and survival signaling. Focal adhesion kinase has been shown to be overexpressed in many types of tumors, including breast cancer at early stages o...
ORGANISM(S): Homo sapiens 
2009-08-22 | E-GEOD-11581 | biostudies-arrayexpress
TranscriptomicsExpression profiling of breast cancer cell lines MCF-7 and MCF-7R4
Human breast cancer cell line MCF-7 is usually sensitive to chemotherapy drug BMS-554417, an insulin receptor (IR) and insulin-like growth factor receptor (IGFR) inhibitor. However, through step-wise increase in BMS-554417 doses in culture media, we were able able to screen and select a single MCF-7...
ORGANISM(S): Homo sapiens 
2009-11-05 | E-GEOD-18912 | biostudies-arrayexpress
ModelsWei2019 - Mathematical modeling of tumor growth The MCF-7 breast cancer cell line
This is a mathematical model describing MCF-7 cancer cell growth with interaction between tumor cells, estradiol (hormone-dependent tumor growth), natural killer cells, cytotoxic T lymphocytes and white blood cells.
2019-09-09 | MODEL1909090002 | BioModels
Immuno-oncology 
TranscriptomicsEffects of global system for mobile communications 1800 MHz radiofrequency electromagnetic fields on gene expression in MCF-7 cells
Despite many studies over a decade, it still remains ambiguous as to the real biological effects induced by radiofrequency electromagnetic fields (RF EMF). Epidemiological studies indicates that long-term exposure to EMF could increase the risk of breast cancer. Some reports have showed that in vitr...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-22991 | biostudies-arrayexpress
TranscriptomicsProlonged Drug Selection of Breast Cancer Cells and Enrichment of Cancer Stem Cell Characteristics.
Background: Cancer stem cells are presumed to have virtually unlimited proliferative and self-renewal abilities and to be highly resistant to chemotherapy, a feature that is associated with overexpression of ATP-binding cassette transporters. We investigated whether prolonged continuous selection of...
ORGANISM(S): Homo sapiens 
2011-09-25 | E-GEOD-24460 | biostudies-arrayexpress
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