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ProteomicsComprehensive characterization of Minichromosome Maintenance Complex (MCM) protein interactions using affinity and proximity purifications coupled to mass spectrometry.
This project is the complete interactome of the Minichromosome Maintenance (MCM) complex by using AP-MS and BioID approaches for all the different MCM proteins. Overall, our analysis identified unique and shared interaction partners and proteins enriched for distinct biological processes including D...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000080198 | MassIVE
ProteomicsComprehensive characterization of Minichromosome Maintenance Complex (MCM) protein interactions using affinity and proximity purifications coupled to mass spectrometry.
This project is the complete interactome of the Minichromosome Maintenance (MCM) complex by using AP-MS and BioID approaches for all the different MCM proteins. Overall, our analysis identified unique and shared interaction partners and proteins enriched for distinct biological processes including D...
ORGANISM(S): Homo sapiens (Human) 
2016-08-09 | PXD004089 | Pride
Ap-ms Bioid Mcm complex 
ProteomicsDestabilization of the MiniChromosome Maintenance (MCM) complex modulates the cellular response to DNA double strand breaks induced by Etoposide.
DNA replication during S phase involves thousands of replication forks that must be coordinated to ensure that every DNA section is only replicated once. The minichromosome maintenance proteins, MCM2 to MCM7, form a heteromeric DNA helicase required for both initiation of DNA replication and elongat...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD009539 | Pride
Dna repair Mcm protein Etoposide Dna damage Homologous recombination 
UnknownSolving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes.
Not available
S-EPMC9568601 | biostudies-literature
UnknownStructural analysis of the Sulfolobus solfataricus MCM protein N-terminal domain.
Not available
S-EPMC2425480 | biostudies-literature
UnknownSchizosaccharomyces pombe minichromosome maintenance-binding protein (MCM-BP) antagonizes MCM helicase.
Not available
S-EPMC3190919 | biostudies-literature
TranscriptomicsGenome-wide localization of ORC and MCM binding sites and identification of replication origins in S. pombe
DNA replication of eukaryotic chromosomes initiates at a number of discrete loci, called replication origins. Distribution and regulation of origins are important for complete duplication of the genome. Here, we determined locations of Orc1 and Mcm6, components of pre-replicative complex (pre-RC),...
ORGANISM(S): Schizosaccharomyces pombe 
2010-06-11 | E-GEOD-6523 | biostudies-arrayexpress
ProteomicsMH20200824_12plex_Mouse MCM cardiomyocytes_LabF
MH20200824_12plex_Mouse MCM cardiomyocytes_LabF-24h-r1
ORGANISM(S): Mus Musculus 
2024-03-29 | PXD051081 |
ProteomicsInhibitory effect of miR-183 on MCM family members
MYCN and HDAC2 jointly repress the transcription of tumor suppressive micro RNA miR-183 in neuroblastoma. Enforced miR-183 expression induces neuroblastoma cell death and inhibits anchorage-independent colony formation and subcutaneous xenograft growth in mice. We here aimed to unravel the miR-183 s...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003596 | Pride
Label-free proteomics Cell cycle progression Eukaryotic genome replication Oncogene Genomic integrity 
GenomicsExpression data in patients with familial (FCS) and multifactorial chylomicronemia (MCM)
Expression data in patients with familial (FCS) and multifactorial chylomicronemia (MCM)
PRJNA629355 | ENA
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