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PAR-iCLIP MCMV infection
4sU-seq of MCMV
cRNA-seq of MCMV
Reactivation of latent HCMV is a significant infectious complication of organ transplantation, and current therapies target viral replication once reactivation of transcriptionally silent, latent virus has already occurred. The specific molecular pathways that activate viral gene expression are not...
ORGANISM(S): Mus musculus 
dSLAM-seq of MCMV
mCMV m06 deletion mutants were sequenced and compared for additional deletions.
Reconstitution of cytomegalovirus (CMV)-specific immunity following transplant remains a primary clinical objective to prevent CMV disease, and adoptive immunotherapy of CMV-specific T cells can be an effective therapeutic approach. Due to the persistence of CMV, most CMV-specific CD8+ T cells becom...
ORGANISM(S): Mus musculus 
One goal of viral infection is to reprogram the host cell to optimize viral replication. As part of this process, viral miRNAs may compete for components of the miRNA/siRNA pathway as well as regulate cellular targets. Mouse Cytomegalovirus has been described to generate large numbers of viral miRNA...
ORGANISM(S): Mus musculus 
Ribosome profiling of MCMV
Type I interferons are critical anti-viral cytokines during virus infections and have also been implicated in the pathogenesis of systemic lupus erythematosus (SLE). The secretion of type I interferon of pDCs is modulated by Siglec-H, a DAP12 associated receptor on pDCs. We showed that Siglec-H defi...
ORGANISM(S): Mus musculus 
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