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Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas
Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas
MCPyV targets NDRG1 to promote cellular proliferation
Merkel cell polyomavirus (MCPyV) is the first human polyomavirus etiologically associated with Merkel cell carcinoma (MCC), a rare and aggressive form of skin cancer. Similar to other polyomaviruses, MCPyV encodes early T antigen genes, a viral oncogene required for MCC tumor growth. To identify the...
ORGANISM(S): Homo sapiens 
2019-09-13 | GSE137328 | GEO
RNA seq analysis comparing uninfected to MCPyV-infected 2D monolayer or 3D spheroids
Human tumor virus infections account for ~10% of the world’s cancer cases. However, studies on the life cycle of small DNA tumor viruses have been hampered primarily due to the lack of virus culture systems that allow for robust replication and high-level infection in host cells. Thus, studies invol...
ORGANISM(S): Homo sapiens 
2026-05-29 | GSE311065 | GEO
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