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GenomicsTranscriptomic differences between radioresistant MDA-MB-468 and parental MDA-MB-468
Transcriptomic differences between radioresistant MDA-MB-468 and parental MDA-MB-468
PRJNA1223424 | ENA
TranscriptomicsTranscription profiling of human rapamycin treated of MDA-MB-468 breast cancer cell line and MDA-MB-468 xenografts
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in multiple intracellular signaling pathways promoting tumor growth. mTOR is aberrantly activated in a significant portion of breast cancers and is a promising target for treatment. Rapamycin and its analogues are in clinical...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-18571 | biostudies-arrayexpress
TranscriptomicsALDH1A3-mediated gene expression in MDA-MB-231 cells and MDA-MB-468 cells
To determine the effect ALDH1A3 expression on global gene expression in MDA-MB-231 cells and MDA-MB-468 cells In MDA-MB-231 cells, ALDH1A3 was overexperssed (have low endogenous levels of ALDH1A3) and compared to MSCV empty vector control. In MDA-MB-468 cells that have high endogenous levels of ALDH...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49322 | biostudies-arrayexpress
MetabolomicsSingle-cell lipidomic analysis of the Epithelial-Mesenchymal Transition (EMT) using MALDI-MSI

EMT is a metastasis-promoting process whose heterogeneity has been extensively studied at a gene expression level. EMT also involves reprogramming of lipid metabolism, however there has been little focus on heterogeneity on the lipid level. Here, we use MALDI-MSI to determine the levels of variou...

2026-04-15 | MTBLS12650 | MetaboLights
GenomicsRNA-Sequencing of MDA-MB-468 TNBC cells, carboplatin-resistant isogenic MDA-MB-468 cells, and dN90-beta-catenin-overexpressing MDA-MB-468 cells
RNA-Sequencing of MDA-MB-468 TNBC cells, carboplatin-resistant isogenic MDA-MB-468 cells, and dN90-beta-catenin-overexpressing MDA-MB-468 cells
PRJEB44182 | ENA
TranscriptomicsGene Expression Microarrays data from human breast cancer cell lines MDA-MB-468 and SkBr3 treated for 48h with 1mM and 4mM of Metformin with non-treated control samples
This study was designed to investigate the Metformin mode of action in different subtypes of breast cancer using cell and molecular, and systems biology techniques. To that end, several concentrations of Metformin have been used. Besides, five different breast cancer cell lines representing the five...
ORGANISM(S): Homo sapiens 
2019-03-07 | E-MTAB-7737 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of MDA-MB-468 cells following p53-R273H mutant knock-down
A total of 58 genes were up-regulated (> 1.5 fold-change) while 117 genes were down-regulated Microarray experiments were performed in duplicate as follows: MDA-MB-468 cells were transduced with lentiviral shRNA targeting endogenous p53-R273H mutant (p53si-1)or a non-targeting shRNA (NS). Total RNA ...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-65967 | biostudies-arrayexpress
TranscriptomicsRNA-Sequencing of MDA-MB-468 TNBC cells, carboplatin-resistant isogenic MDA-MB-468 cells, and dN90-beta-catenin-overexpressing MDA-MB-468 cells
In this experiment, we generated isogenic carboplatin-resistant MDA-MB-468 cells displaying a 5x increase in IC50 in respect to the parental cell line. We set out to compare the transcriptome of these cell lines, together with MDA-MB-468 cells overexpressing a constitutively active form of beta-cate...
ORGANISM(S): Homo sapiens 
2021-07-09 | E-MTAB-10337 | biostudies-arrayexpress
TranscriptomicsmiR-522 Overexpression in MDA-MB-468
Over-expression of miR-522 mimic or control miR mimic in MDA-MB-468 breast cancer cell line
ORGANISM(S): Homo sapiens 
2014-06-30 | E-MTAB-2110 | biostudies-arrayexpress
TranscriptomicsRNA-seq of HSPA8 knockdown in MDA-MB-468 cells
We used three siRNAs to silence HSPA8 in MDA-MB-468 cells, and then used RNA-seq to compare HSPA8 knockdown cells with the controls.
ORGANISM(S): Homo sapiens 
2025-11-13 | E-MTAB-16073 | biostudies-arrayexpress
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