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TranscriptomicsEffect of pharmacological inhibition of ASBT on bile composition and sclerosing cholangitis in mdr2 knockout mice
We report the effect of a potent pharmacological inhibition of ASBT in mdr2 -/- mice, compared to genetic and treatment controls using RNA-sequencing. Through quantification of mRNA in liver samples, we found significant upregulation of anti-inflammatory and anti-fibrotic gene signatures in mdr2-/-...
ORGANISM(S): Mus musculus 
2016-02-17 | E-GEOD-66231 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of MDR2 knockout mice vs heterozygotes sampled at multiple time points in the early stages of liver carcinogenesis to identify the molecular mechanisms of HCC initiation and promotion
We studied the molecular mechanisms of hepatocellular carcinoma (HCC) initiation and promotion using the Mdr2-knockout (Mdr2-KO) mice at pre-cancerous stages of liver disease. These mice lack the liver-specific P-glycoprotein responsible for phosphatidylcholine transport across the canalicular membr...
ORGANISM(S): Mus musculus 
2007-11-23 | E-GEOD-4612 | biostudies-arrayexpress
GenomicsMus musculus strain:Mdr2-KO
Mdr2-KO whole exome sequencing
PRJNA242963 | ENA
GenomicsMus musculus strain:Mdr2-KO
Whole Genome sequencing of Mdr2-knockout
PRJNA243010 | ENA
TranscriptomicsMurine liver tissue, Mdr2-/+ control vs Mdr2-KO
Chronic liver inflammation precedes the majority of hepatocellular carcinomas (HCC). Here, we explore the connection between chronic inflammation and DNA methylation in the liver at the late precancerous stages of HCC development in Mdr2/Abcb4-knockout (Mdr2-KO) mice, a model of inflammation-mediate...
ORGANISM(S): Mus musculus 
2015-03-01 | E-GEOD-64097 | biostudies-arrayexpress
TranscriptomicsGene Expression Data for male C57BL/6, Mdr2-KO and Mdr2-KO/IL6-KO at the age of 14 months
Chronic inflammation is a common underlying condition associated with tumor development, accounting for approximately 20% of human cancers. This association is especially apparent in Hepatocellular carcinoma (HCC), which often develops on the background of chronic hepatitis and hepatic fibrosis, slo...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-37468 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from Mdr2-knockout mice to investigate mechanisms of carcinogenesis
Mouse models of hepatocellular carcinoma (HCC) simulate specific subgroups of human HCC. We investigated hepatocarcinogenesis in Mdr2-KO mice, a model of inflammation-associated HCC, using gene expression profiling and immunohistochemical analyses. Gene expression profiling demonstrated that althoug...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8642 | biostudies-arrayexpress
TranscriptomicsGene Expression Data for female C57BL/6, Mdr2-KO and Mdr2-KO/IL6-KO at the age of 14 months
Chronic inflammation is a common underlying condition associated with tumor development, accounting for approximately 20% of human cancers. This association is especially apparent in Hepatocellular carcinoma (HCC), which often develops on the background of chronic hepatitis and hepatic fibrosis, slo...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-37559 | biostudies-arrayexpress
TranscriptomicsSpecific Genomic and Transcriptomic Aberrations in Tumors Induced by Partial Hepatectomy of a Chronically Inflamed Murine Liver [aCGH]
Background & Aims. Resection of hepatocellular carcinoma (HCC) tumors by partial hepatectomy (PHx) is associated with promoting hepatocarcinogenesis. We have previously reported that PHx promotes hepatocarcinogenesis in the Mdr2-knockout (Mdr2-KO) mouse, a model for inflammation-mediated HCC. Now, w...
ORGANISM(S): Mus musculus 
2015-04-01 | E-GEOD-61423 | biostudies-arrayexpress
Methylation profilingMurine liver tissue, Mdr2-/+ control vs Mdr2-KO
Chronic liver inflammation precedes the majority of hepatocellular carcinomas (HCC). Here, we explore the connection between chronic inflammation and DNA methylation in the liver at the late precancerous stages of HCC development in Mdr2/Abcb4-knockout (Mdr2-KO) mice, a model of inflammation-mediate...
ORGANISM(S): Mus musculus 
2015-03-01 | GSE64097 | GEO
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