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Children have a lower incidence and mortality from acute lung injury than adults, and infections are the most common event associated with acute lung injury (ALI). To study the effects of age on susceptibility to ALI, we investigated the responses to microbial products combined with mechanical vent...
ORGANISM(S): Mus musculus 
This series contain mouse and rat lung samples treated with mechanical ventilation and corresponded controls.
ORGANISM(S): Mus musculus 
This experiment investigated the role of mechanical ventilation (MV) in modulating lung's transcriptional response to LPS. Twenty four C57/B6 male mice were randomized to four groups: 1. Control, 2. MV, 3. LPS and 4. MV+LPS. Expression profiling of whole lungs revealed a significant augmentation...
ORGANISM(S): Mus musculus 
Mechanical ventilation (MV) has been associated with inflammation and endothelial damage, causing local injury in the lung, and in off-target organs such as the brain and kidneys. We investigate the association between MV and changes in plasma protein levels for relatively healthy patients undergoin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-07-16 | MSV000095347 | MassIVE
Impact of aging on pulmonary cellular responses during mechanical ventilation
Introduction: The ideal ventilation strategy for patients with massive brain damage requires better elucidation. We hypothesized that in the presence of massive brain injury, a ventilation strategy using low (6 mL/kg) tidal volume (VT) ventilation with open lung positive end-expiratory pressure set ...
ORGANISM(S): Rattus norvegicus 
Effect of mechanical ventilation and mechanical ventilationon with positive end expiratory pressure(PEEP) application on diaphragmatic dysfunction in rabbits
This series contain unilateral mechanical ventilated canine lung samples.
ORGANISM(S): Canis familiaris 
Single-nucleus transcriptomic profiling of the diaphragm during mechanical ventilation
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