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MetabolomicsMechanisms of action of bile acids in pediatric gastroesophageal reflux: Exploration through non-targeted and targeted metabolomics methods

Purpose: To investigate the pathogenesis of pediatric bile reflux gastritis (BRG) using non-targeted and targeted metabolomics analyses of the changes and content differences of bile acids (BAs) in gastric juice. Methods: Data from 25 pediatric BRG patients treated at Jinhua Maternal and Child He...

2025-12-04 | MTBLS13450 | MetaboLights
MetabolomicsMechanisms of action of bile acids in pediatric gastroesophageal reflux: Exploration through non-targeted and targeted metabolomics methods

Purpose: To investigate the pathogenesis of pediatric bile reflux gastritis (BRG) using non-targeted and targeted metabolomics analyses of the changes and content differences of bile acids (BAs) in gastric juice. Methods: Data from 25 pediatric BRG patients treat...

2025-12-05 | MTBLS13459 | MetaboLights
MetabolomicsMetabolomics-based screening of the Malaria Box reveals both novel and established mechanisms of action
Not available
ORGANISM(S): Plasmodium falciparum 
ST000414 | MetabolomicsWorkbench
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of KP46-treated HCT 116 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo sapiens (Human) 
2022-02-24 | PXD004765 | Pride
Metallodrug Proteome profiling Mechanism of action Functional protein groups Response profiling 
MetabolomicsCommunity metabolomics provides insights into mechanisms of pollution-induced community tolerance of periphyton

Chemical pollution is a major concern for freshwater ecosystems, but the impact and mechanisms of chemical stressors on communities are barely understood. Pollution stress beyond natural homeostatic capacities can trigger succession of tolerant species within a community, enhancing the overall co...

2022-02-11 | MTBLS3595 | MetaboLights
TranscriptomicsNeurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus)
This SuperSeries is composed of the following subset Series: GSE33888: Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 1 of 10) GSE33893: Neurotoxicogenomic investigations to assess mechan...
ORGANISM(S): Colinus virginianus 
2011-11-22 | E-GEOD-27653 | biostudies-arrayexpress
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of KP1537-treated SW480 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080730 | MassIVE
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of untreated HCT 116 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080737 | MassIVE
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of KP772-treated SW480 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080736 | MassIVE
ProteomicsResponse Profiling Using Shotgun Proteomics Enables Establishing Global Metallodrug Mechanisms of Action - cytoplasmic proteins of KP1339-treated SW480 epithelial cells
Response profiling using shotgun proteomics for establishing global metallodrug mechanisms of action in two colon carcinoma cell lines, HCT116 and SW480, was applied and evaluated with the clinically approved arsenic trioxide. Surprisingly, the complete established mechanism of action of arsenic tr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080734 | MassIVE
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