PURPOSE: To explore molecular mechanisms affecting nutritional risk and neurodevelopment in children with congenital heart disease (CHD) by combining transcriptome and metabolome analysis.

METHODS: A total of 26 blood and serum samples from 3 groups of chil...

Xuanfei Heji (XFHJ) is a hospital-formulated herbal preparation and has demonstrated significant clinical efficacy in managing chronic obstructive pulmonary disease (COPD). However, its systemic pharmacological mechanisms and the interplay between host metabolism and microbial communities remain ...

Variation in food availability can shape host susceptibility and pathogen virulence, thereby impacting disease outcomes. An ad libitum diet may enhance host physiology and immunity but it can also favor pathogen proliferation. Here, we investigated how food availability (ad libitum vs. starvation...

Respiratory viral co-infections in children with Mycoplasma pneumoniae pneumonia (MPP) are common and cause severe clinical manifestations. However, the exact pathogenic mechanisms of MPP co-infections are still unclear. In this study, we conducted a large-scale clinical analysis of 3,106 MPP pat...

In recent years, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease globally. Studies indicate that the gut-liver axis plays an important role in the occurrence and development of this disease. Our previous studies showed that the gut microbiota and gut meta...

BACKGROUND AND HYPOTHESIS: It is presently unclear why there is a high prevalence of periodontal disease in individuals living with chronic kidney disease. Whilst some have argued that periodontal disease causes chronic kidney disease, we hypothesized that alterations in saliva ...