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ProteomicsRegulation of Cortical Neurogenesis by MED13L via Transcriptional Priming and its Implications for MED13L Syndrome
MED13L is highly susceptible to neurodevelopmental disorders, yet the underlying developmental mechanisms remain poorly understood. We developed a gene knockout mouse model of MED13L syndrome to elucidate these mechanisms. Homozygous Med13l-null mice exhibit neonatal lethality and severe cortical ne...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-09 | PXD055844 | Pride
Mediator complex Neural progenitors Med13l syndrome Neurogenesis Cerebral cortex 
ProteomicsRegulation of Cortical Neurogenesis by MED13L via Transcriptional Priming and its Implications for MED13L Syndrome
MED13L is highly susceptible to neurodevelopmental disorders, yet the underlying developmental mechanisms remain poorly understood. We developed a gene knockout mouse model of MED13L syndrome to elucidate these mechanisms. Homozygous Med13l-null mice exhibit neonatal lethality and severe cortical ne...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-09 | PXD055474 | Pride
Mediator complex Neural progenitors Med13l syndrome Neurogenesis Cerebral cortex 
GenomicsRegulation of Cortical Neurogenesis by MED13L via Transcriptional Priming and its Implications for MED13L Syndrome
Regulation of Cortical Neurogenesis by MED13L via Transcriptional Priming and its Implications for MED13L Syndrome
PRJNA1160297 | ENA
TranscriptomicsRegulation of Cortical Neurogenesis by MED13L via Transcriptional Priming and its Implications for MED13L Syndrome
MED13L is highly susceptible to neurodevelopmental disorders, yet the underlying developmental mechanisms remain poorly understood. We developed a gene knockout mouse model of MED13L syndrome to elucidate these mechanisms. Homozygous Med13l-null mice exhibit neonatal lethality and severe cortical ne...
ORGANISM(S): Mus musculus 
2025-06-30 | GSE277054 | GEO
UnknownRedefining the MED13L syndrome.
Not available
S-EPMC4592099 | biostudies-literature
UnknownRegulation of cortical neurogenesis by MED13L via transcriptional priming and its implications for MED13L syndrome.
Not available
S-EPMC12331956 | biostudies-literature
UnknownNovel de novo heterozygous loss-of-function variants in MED13L and further delineation of the MED13L haploinsufficiency syndrome.
Not available
S-EPMC4613466 | biostudies-literature
Unknown[Clinical phenotype and genetic analysis of MED13L syndrome].
Not available
S-EPMC7389282 | biostudies-literature
UnknownAberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in MED13L syndrome fibroblasts.
Not available
S-EPMC8844603 | biostudies-literature
UnknownMolecular and Functional Characterisation of a Novel Intragenic 12q24.21 Deletion Resulting in MED13L Haploinsufficiency Syndrome.
Not available
S-EPMC10385642 | biostudies-literature
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