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GenomicsReduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified meduloblastoma
Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified meduloblastoma
PRJNA600255 | ENA
GenomicsReduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified meduloblastoma [expression]
Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified meduloblastoma [expression]
PRJNA600257 | ENA
GenomicsReduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified meduloblastoma [ChIP-seq]
Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified meduloblastoma [ChIP-seq]
PRJNA600250 | ENA
GenomicsReduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified meduloblastoma [RNA-seq]
Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified meduloblastoma [RNA-seq]
PRJNA600253 | ENA
TranscriptomicsReduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified meduloblastoma
This SuperSeries is composed of the SubSeries listed below.
ORGANISM(S): Homo sapiens 
2020-09-01 | GSE143386 | GEO
TranscriptomicsReduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified meduloblastoma [expression]
MYC is a driver oncogene in many cancers. Inhibition of MYC promises high therapeutic potential, but specific MYC inhibitors remain unavailable for clinical use. Previous studies suggest that MYC amplified Medulloblastoma cells are vulnerable to HDAC inhibition. Using co-immunoprecipitation, mass sp...
ORGANISM(S): Homo sapiens 
2020-09-01 | GSE143384 | GEO
TranscriptomicsBeta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma.
Our study showed that propranolol, carvedilol and nebivolol inhibited medulloblastoma cell proliferation and invasion by affecting energy metabolism pathways (OXPHOS and glycolysis) and by triggering a metabolic catastrophe that deprived tumor cells of their adaptive bioenergetics capacities. To bet...
ORGANISM(S): Homo sapiens 
2022-05-31 | GSE191165 | GEO
TranscriptomicsReduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified meduloblastoma [RNA-seq]
MYC is a driver oncogene in many cancers. Inhibition of MYC promises high therapeutic potential, but specific MYC inhibitors remain unavailable for clinical use. Previous studies suggest that MYC amplified Medulloblastoma cells are vulnerable to HDAC inhibition. Using co-immunoprecipitation, mass sp...
ORGANISM(S): Homo sapiens 
2020-09-01 | GSE143379 | GEO
GenomicsReduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified meduloblastoma [ChIP-seq]
MYC is a driver oncogene in many cancers. Inhibition of MYC promises high therapeutic potential, but specific MYC inhibitors remain unavailable for clinical use. Previous studies suggest that MYC amplified Medulloblastoma cells are vulnerable to HDAC inhibition. Using co-immunoprecipitation, mass sp...
ORGANISM(S): Homo sapiens 
2020-09-01 | GSE143376 | GEO
UnknownRNA expression of the molecular signature genes for metastasis in colorectal cancer.
Not available
S-EPMC3954856 | biostudies-literature
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